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Nuclear magnetic resonance-based lipid metabolite profiles for differentiation of patients with liver cirrhosis with and without hepatocellular carcinoma

Background: Hepatocellular carcinoma is frequently unrecognized in its early stage limiting the access to the first therapeutic steps resulting in a low cure rate. Therefore, an early diagnosis is crucial. In this scenario the analysis of lipidome and metabolome emerged as a promising tool for early detection. Aims: Aim of the study was to characterize metabolomic profiles as novel markers of early hepatocellular carcinoma. Methods: Serum basal levels of metabolites, isolated from a cohort of...

Impact of atrial fibrillation on outcomes in stroke patients with tandem occlusions treated with thrombectomy: A multicentre study

Background: Tandem occlusions, involving simultaneous extracranial and intracranial artery blockages, represent a complex subtype of acute ischemic stroke treated with mechanical thrombectomy (MT). However, to date, the impact of atrial fibrillation (AF) on outcomes in this population remains unclear. This study aimed to evaluate the safety and efficacy of MT in patients with tandem occlusions, comparing those with AF to their counterparts without AF. Methods: We performed a multicentre, retr...

Radical hemithorax radiotherapy induces an increase in circulating PD-1+ T lymphocytes and in the soluble levels of PD-L1 in malignant pleural mesothelioma patients: a possible synergy with PD-1/PD-L1 targeting treatment?

Malignant Pleural Mesothelioma (MPM) is an aggressive tumor associated with asbestos exposure, characterized by a poor prognosis, managed with surgery, chemotherapy and radiotherapy. Recently, immunotherapy gives a survival advantage compared to chemotherapy, but limited to the non-epithelioid histotype, the rarest type. Radical hemithorax radiotherapy (RHRT) improves the Overall Survival (OS) of MPM patients, irrespective of histotype, and is able to induce immunomodulatory effects. In this ...

Sudden death of an athlete with concealed arrhythmogenic cardiomyopathy

We report the case of a professional soccer athlete who died suddenly due to early arrhythmogenic cardiomyopathy that was not diagnosed at the time of preparticipation screening. Exercise testing had repeatedly shown effort-induced premature ventricular beats with normal echocardiography, a finding that was considered reassuring. However, there is emerging evidence that cardiac diseases characterized by focal ventricular scarring may not cause wall motion abnormalities and can be revealed onl...

Orientational Dynamics of Long Flexible Fibers in Wall-Bounded Turbulence

In this paper, we study numerically the role of fiber length and flexibility on the orientational dynamics of slender fibers in turbulent channel flow. We consider fibers of different flexibility at varying aspect ratio, up to lengths being comparable to the channel height. These fibers are constructed by constraining a large number of sub-Kolmogorov rods in a single chain, alongside a bending stiffness torque that allows to prescribe a finite value of the fiber rigidity. To perform our analy...

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Prodotti recenti

Nuclear magnetic resonance-based lipid metabolite profiles for differentiation of patients with liver cirrhosis with and without hepatocellular carcinoma

Impact of atrial fibrillation on outcomes in stroke patients with tandem occlusions treated with thrombectomy: A multicentre study

Radical hemithorax radiotherapy induces an increase in circulating PD-1+ T lymphocytes and in the soluble levels of PD-L1 in malignant pleural mesothelioma patients: a possible synergy with PD-1/PD-L1 targeting treatment?

Sudden death of an athlete with concealed arrhythmogenic cardiomyopathy

Orientational Dynamics of Long Flexible Fibers in Wall-Bounded Turbulence

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