We present a quantitative numerical analysis of dielectric microbead detection experiments with nanoribbons operated in the AC small signal regime. To this purpose, a comprehensive model of nanoribbon operation in electrolyte environment and with DC/AC signals is extended to include the effect of site-binding charges in DC, transient and AC conditions. The model is calibrated against DC measurements and pH-transients data from the literature. The impact of the microfluidic chamber size, the interconnects and the site-binding charge is investigated. The calibrated model suggests that the impedance response to micron-sized beads cannot be explained without also taking into account the bead surface charge.

Analysis of Dielectric Microbead Detection by Impedance Spectroscopy with Nanoribbons

SCARBOLO, Paolo;SELMI, Luca
2016

Abstract

We present a quantitative numerical analysis of dielectric microbead detection experiments with nanoribbons operated in the AC small signal regime. To this purpose, a comprehensive model of nanoribbon operation in electrolyte environment and with DC/AC signals is extended to include the effect of site-binding charges in DC, transient and AC conditions. The model is calibrated against DC measurements and pH-transients data from the literature. The impact of the microfluidic chamber size, the interconnects and the site-binding charge is investigated. The calibrated model suggests that the impedance response to micron-sized beads cannot be explained without also taking into account the bead surface charge.
978-1-5090-1493-4
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11390/1101207
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