Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the proliferation of Langerhans cells in different organs. Clinical dermatological pictures include a variety of localized or widespread lesions, such as red-brown papules, nodules, ulcers, seborrheic dermatitis-like eruptions, hypopigmentation, and nail changes. Dermatoscopic examination may aid in identifying some characteristic findings, including white-yellow scales/crusts, hypo- or hyper-pigmented spots, purplish-red globules or patches, and scar-like streaks with ectatic vessels. Additionally, when it comes to nails, purpuric striae and onycholysis may also be seen on dermatoscopy. However, dermatoscopic features are not pathognomonic and should be integrated to other diagnostic findings.
Langerhans Cell Histiocytosis
Errichetti E.;Stinco G.
2026-01-01
Abstract
Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the proliferation of Langerhans cells in different organs. Clinical dermatological pictures include a variety of localized or widespread lesions, such as red-brown papules, nodules, ulcers, seborrheic dermatitis-like eruptions, hypopigmentation, and nail changes. Dermatoscopic examination may aid in identifying some characteristic findings, including white-yellow scales/crusts, hypo- or hyper-pigmented spots, purplish-red globules or patches, and scar-like streaks with ectatic vessels. Additionally, when it comes to nails, purpuric striae and onycholysis may also be seen on dermatoscopy. However, dermatoscopic features are not pathognomonic and should be integrated to other diagnostic findings.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
