The present invention relates to a process for the preparation of Cyclen, in its turn widely employed in the manufacturing of a variety of macrocyclic gadolinium complexes for use as MRI contrast agents. The said process comprises an efficient coupling of glyoxal with triethylene tetramine and the subsequent reduction of the obtained intermediate derivative with an aluminium based reducing agent. The process is particularly advantageous for the industrial scale as it avoids the use and/or for...
The present invention relates to a method for determining the presence and/or amount of at least one analyte (T) that may be contained in a sample. The method comprises: (a) a recognition step during which said sample (E) is placed in the presence of at least one primary probe (1), in order to form, if necessary, a primary complex (C1), (b) a development step during which at least one developing reagent is added, capable of forming, starting from the primary probe (1) of said primary complex ...
The present invention relates to a nucleotide probe specific for Campylobacter jejuni, Campylobacter coli, Campylobacter lari and Campylobacter upsaliensis, its uses, and methods for detecting said microorganisms in a sample of interest, and kits comprising said probe and suitable reagents.