This paper investigates the response of a nanoelectrode based capacitive biosensor to the presence of single and double strands of DNA/PNA. The expected admittance spectrum for an idealized system with cylindrical symmetry, where the biomolecule is represented by a simple dielectric and charged rod, is calculated over a broad frequency range extending from below to above the electrolyte’s dielectric relaxation cut-off frequency. DNA and PNA hybridization is also considered. The results provide indications on optimum detection conditions for admittance based DNA biosensors.
On the response of nanoelectrode capacitive biosensors to DNA and PNA strands
PITTINO, Federico;PALESTRI, Pierpaolo;SELMI, Luca;
2013-01-01
Abstract
This paper investigates the response of a nanoelectrode based capacitive biosensor to the presence of single and double strands of DNA/PNA. The expected admittance spectrum for an idealized system with cylindrical symmetry, where the biomolecule is represented by a simple dielectric and charged rod, is calculated over a broad frequency range extending from below to above the electrolyte’s dielectric relaxation cut-off frequency. DNA and PNA hybridization is also considered. The results provide indications on optimum detection conditions for admittance based DNA biosensors.File in questo prodotto:
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