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Clinical validity of a DPYD-based pharmacogenetic test to predict severe toxicity to fluoropyrimidines 1-gen-2015 Toffoli, Giuseppe; Giodini, Luciana; Buonadonna, Angela; Berretta, Massimiliano; De Paoli, Antonino; Scalone, Simona; Miolo, Gianmaria; Mini, Enrico; Nobili, Stefania; Lonardi, Sara; Pella, Nicoletta; Lo Re, Giovanni; Montico, Marcella; Roncato, Rossana; Dreussi, Eva; Gagno, Sara; Cecchin, Erika
Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma 1-gen-2016 Hattinger, Claudia M; Biason, Paola; Iacoboni, Erika; Gagno, Sara; Fanelli, Marilù; Tavanti, Elisa; Vella, Serena; Ferrari, Stefano; Roli, Andrea; Roncato, Rossana; Giodini, Luciana; Scotlandi, Katia; Picci, Piero; Toffoli, Giuseppe; Serra, Massimo
Pregnane X receptor, constitutive androstane receptor and hepatocyte nuclear factors as emerging players in cancer precision medicine 1-gen-2016 De Mattia, Elena; Cecchin, Erika; Roncato, Rossana; Toffoli, Giuseppe
Pharmacogenomics of Targeted Agents for Personalization of Colorectal Cancer Treatment 1-gen-2017 Bignucolo, A; De Mattia, E; Cecchin, E; Roncato, R; Toffoli, G
Genetic biomarkers for hepatocellular cancer risk in a caucasian population 1-gen-2017 De Mattia, Elena; Cecchin, Erika; Polesel, Jerry; Bignucolo, Alessia; Roncato, Rossana; Lupo, Francesco; Crovatto, Marina; Buonadonna, Angela; Tiribelli, Claudio; Toffoli, Giuseppe
Ubiquitous Pharmacogenomics (U-PGx): The Time for Implementation is Now. An Horizon2020 Program to Drive Pharmacogenomics into Clinical Practice 1-gen-2017 Cecchin, Erika; Roncato, Rossana; Guchelaar, Hendrik J; Toffoli, Giuseppe
Cost Evaluation of Irinotecan-Related Toxicities Associated With the UGT1A1*28 Patient Genotype 1-gen-2017 Roncato, R; Cecchin, E; Montico, M; De Mattia, E; Giodini, L; Buonadonna, A; Solfrini, V; Innocenti, F; Toffoli, G
Identification of Novel Somatic TP53 Mutations in Patients with High-Grade Serous Ovarian Cancer (HGSOC) Using Next-Generation Sequencing (NGS) 1-gen-2018 Garziera, Marica; Cecchin, Erika; Canzonieri, Vincenzo; Sorio, Roberto; Giorda, Giorgio; Scalone, Simona; De Mattia, Elena; Roncato, Rossana; Gagno, Sara; Poletto, Elena; Romanato, Loredana; Sartor, Franca; Polesel, Jerry; Toffoli, Giuseppe
Association of STAT-3 rs1053004 and VDR rs11574077 With FOLFIRI-Related Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients 1-gen-2018 De Mattia, Elena; Cecchin, Erika; Montico, Marcella; Labriet, Adrien; Guillemette, Chantal; Dreussi, Eva; Roncato, Rossana; Bignucolo, Alessia; Buonadonna, Angela; D'Andrea, Mario; Coppola, Luigi; Lonardi, Sara; Lévesque, Eric; Jonker, Derek; Couture, Félix; Toffoli, Giuseppe
DPYD gene activity score (GAS) predicts dose-limiting toxicity in fluoropyrimidine-treated colorectal cancer patients 1-gen-2018 DALLE FRATTE, Chiara; Polesel, Jerry; Roncato, Rossana; De Mattia, Elena; Ecca, Fabrizio; Bignucolo, Alessia; Garziera, Marica; Dreussi, Eva; Palazzari, Elisa; Buonadonna, Angela; Guardascione, Michela; Berretta, Massimiliano; Foltran, Luisa; Sartor, Franca; D'Andrea, Mario; Favaretto, Adolfo; Mini, Enrico; Nobili, Stefania; De Paoli, Antonino; Toffoli, Giuseppe; Cecchin, Erika
Improving decision making on DPYD and UGT1A1*28 patients' profiling with an innovative reimbursement strategy 1-gen-2018 Roncato, Rossana; Cecchin, Erika; Toffoli, Giuseppe
The use of pharmacogenetics to increase the safety of colorectal cancer patients treated with fluoropyrimidines 1-gen-2019 De Mattia, Elena; Roncato, Rossana; Dalle Fratte, Chiara; Ecca, Fabrizio; Toffoli, Giuseppe; Cecchin, Erika
New Challenges in Tumor Mutation Heterogeneity in Advanced Ovarian Cancer by a Targeted Next-Generation Sequencing (NGS) Approach 1-gen-2019 Garziera, Marica; Roncato, Rossana; Montico, Marcella; De Mattia, Elena; Gagno, Sara; Poletto, Elena; Scalone, Simona; Canzonieri, Vincenzo; Giorda, Giorgio; Sorio, Roberto; Cecchin, Erika; Toffoli, Giuseppe
Clonal Evolution of TP53 c.375+1G>A Mutation in Pre- and Post- Neo-Adjuvant Chemotherapy (NACT) Tumor Samples in High-Grade Serous Ovarian Cancer (HGSOC) 1-gen-2019 Garziera, Marica; Cecchin, Erika; Giorda, Giorgio; Sorio, Roberto; Scalone, Simona; Mattia, Elena De; Roncato, Rossana; Gagno, Sara; Poletto, Elena; Romanato, Loredana; Ecca, Fabrizio; Canzonieri, Vincenzo; Toffoli, Giuseppe
Germline Polymorphisms in the Nuclear Receptors PXR and VDR as Novel Prognostic Markers in Metastatic Colorectal Cancer Patients Treated With FOLFIRI 1-gen-2019 De Mattia, Elena; Polesel, Jerry; Roncato, Rossana; Labriet, Adrien; Bignucolo, Alessia; Dreussi, Eva; Romanato, Loredana; Guardascione, Michela; Buonadonna, Angela; D'Andrea, Mario; Lévesque, Eric; Jonker, Derek; Couture, Félix; Guillemette, Chantal; Cecchin, Erika; Toffoli, Giuseppe
The Genotype for DPYD Risk Variants in Patients With Colorectal Cancer and the Related Toxicity Management Costs in Clinical Practice 1-gen-2019 Toffoli, Giuseppe; Innocenti, Federico; Polesel, Jerry; De Mattia, Elena; Sartor, Franca; Dalle Fratte, Chiara; Ecca, Fabrizio; Dreussi, Eva; Palazzari, Elisa; Guardascione, Michela; Buonadonna, Angela; Foltran, Luisa; Garziera, Marica; Bignucolo, Alessia; Nobili, Stefania; Mini, Enrico; Favaretto, Adolfo; Berretta, Massimiliano; D'Andrea, Mario; De Paoli, Antonino; Roncato, Rossana; Cecchin, Erika
A TGF-β associated genetic score to define prognosis and platinum sensitivity in advanced epithelial ovarian cancer 1-gen-2019 Gagno, S.; Poletto, E.; Bartoletti, M.; Quartuccio, L.; Romualdi, C.; Garziera, M.; Scalone, S.; Sorio, R.; Dreussi, E.; Zanusso, C.; De Mattia, E.; Roncato, R.; Cecchin, E.; Giorda, G.; De Vita, S.; Dal Bo, M.; Puglisi, F.; Toffoli, G.
FARMAPRICE: A Pharmacogenetic Clinical decision support system for precise and Cost-Effective Therapy 1-gen-2019 Roncato, R.; Cin, L. D.; Mezzalira, S.; Comello, F.; De Mattia, E.; Bignucolo, A.; Giollo, L.; D'Errico, S.; Gulotta, A.; Emili, L.; Carbone, V.; Guardascione, M.; Foltran, L.; Toffoli, G.; Cecchin, E.
Estimating the Effectiveness of DPYD Genotyping in Italian Individuals Suffering from Cancer Based on the Cost of Chemotherapy-Induced Toxicity 1-gen-2019 Fragoulakis, V.; Roncato, R.; Fratte, C. D.; Ecca, F.; Bartsakoulia, M.; Innocenti, F.; Toffoli, G.; Cecchin, E.; Patrinos, G. P.; Mitropoulou, C.
JAK-Inhibitors for the Treatment of Rheumatoid Arthritis: A Focus on the Present and an Outlook on the Future 1-gen-2020 Angelini, Jacopo; Talotta, Rossella; Roncato, Rossana; Fornasier, Giulia; Barbiero, Giorgia; Dal Cin, Lisa; Brancati, Serena; Scaglione, Francesco
Pharmacogenetic score predicts overall survival, progression-free survival and platinum sensitivity in ovarian cancer 1-gen-2020 Gagno, Sara; Bartoletti, Michele; Romualdi, Chiara; Poletto, Elena; Scalone, Simona; Sorio, Roberto; Zanchetta, Martina; De Mattia, Elena; Roncato, Rossana; Cecchin, Erika; Giorda, Giorgio; Toffoli, Giuseppe
Inositol and Non-Alcoholic Fatty Liver Disease: A Systematic Review on Deficiencies and Supplementation 1-gen-2020 Pani, Arianna; Giossi, Riccardo; Menichelli, Danilo; Fittipaldo, Veronica Andrea; Agnelli, Francesca; Inglese, Elvira; Romandini, Alessandra; Roncato, Rossana; Pintaudi, Basilio; Del Sole, Francesco; Scaglione, Francesco
Germline and Somatic Pharmacogenomics to Refine Rectal Cancer Patients Selection for Neo-Adjuvant Chemoradiotherapy 1-gen-2020 De Mattia, Elena; Roncato, Rossana; Palazzari, Elisa; Toffoli, Giuseppe; Cecchin, Erika
CDK4/6 Inhibitors in Breast Cancer Treatment: Potential Interactions with Drug, Gene, and Pathophysiological Conditions 1-gen-2020 Roncato, Rossana; Angelini, Jacopo; Pani, Arianna; Cecchin, Erika; Sartore-Bianchi, Andrea; Siena, Salvatore; De Mattia, Elena; Scaglione, Francesco; Toffoli, Giuseppe
NAFLD-Related Hepatocarcinoma: The Malignant Side of Metabolic Syndrome 1-gen-2021 Michelotti, A.; de Scordilli, M.; Palmero, L.; Guardascione, M.; Masala, M.; Roncato, R.; Foltran, L.; Ongaro, E.; Puglisi, F.
Therapeutic drug monitoring for the cancer patient: challenges and opportunities 1-gen-2021 Angelini, S.; Cecchin, E.; Conti, V.; Dal Piaz, F.; Filippelli, A.; Hrelia, P.; Landini, I.; Menna, P.; Mini, E.; Nobili, S.; Soledad Poetto, A.; Ravegnini, G.; Roncato, R.; Minotti, G.
Cancer Pharmacogenetics: perspective on newly discovered and implemented predictive biomarkers 1-gen-2021 Roncato, R.; Cecchin, E.; Dalle Fratte, C.; Decorti, G.; Del Re, M.; Franca, R.; Nobili, S.; Ravegnini, G.; Stocco, G.; Mini, E.; Toffoli, G.; Cancer Pharmacology Working Group, W. G.
Pharmacovigilance, drug interactions, pharmacogenetics and therapeutic drug monitoring of anticancer agents: a valuable support for clinical practice 1-gen-2021 Raschi, E.; Del Re, M.; Conti, V.; Roncato, R.; Donnini, S.; Marzocco, S.; Ianaro, A.; Filippelli, A.
SMAD3 Host and Tumor Profiling to Identify Locally Advanced Rectal Cancer Patients at High Risk of Poor Response to Neoadjuvant Chemoradiotherapy 1-gen-2021 De Mattia, Elena; Canzonieri, Vincenzo; Polesel, Jerry; Mezzalira, Silvia; Dalle Fratte, Chiara; Dreussi, Eva; Roncato, Rossana; Bignucolo, Alessia; Innocente, Roberto; Belluco, Claudio; Pucciarelli, Salvatore; De Paoli, Antonino; Palazzari, Elisa; Toffoli, Giuseppe; Cecchin, Erika
IL15RA and SMAD3 Genetic Variants Predict Overall Survival in Metastatic Colorectal Cancer Patients Treated with FOLFIRI Therapy: A New Paradigm 1-gen-2021 De Mattia, Elena; Polesel, Jerry; Roncato, Rossana; Labriet, Adrien; Bignucolo, Alessia; Gagno, Sara; Buonadonna, Angela; D’Andrea, Mario; Lévesque, Eric; Jonker, Derek; Couture, Félix; Guillemette, Chantal; Cecchin, Erika; Toffoli, Giuseppe
A Systematic Review and a Meta-Analysis Comparing Prophylactic and Therapeutic Low Molecular Weight Heparins for Mortality Reduction in 32,688 COVID-19 Patients 1-gen-2021 Giossi, Riccardo; Menichelli, Danilo; Pani, Arianna; Tratta, Elena; Romandini, Alessandra; Roncato, Rossana; Nani, Alessandro; Schenardi, Paolo; Diani, Erika; Fittipaldo, Veronica Andrea; Farcomeni, Alessio; Scaglione, Francesco; Pastori, Daniele
Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy 1-gen-2022 Vianello, Caterina; Cocetta, Veronica; Catanzaro, Daniela; Dorn, Gerald W; De Milito, Angelo; Rizzolio, Flavio; Canzonieri, Vincenzo; Cecchin, Erika; Roncato, Rossana; Toffoli, Giuseppe; Quagliariello, Vincenzo; Di Mauro, Annabella; Losito, Simona; Maurea, Nicola; Cono, Scaffa; Sales, Gabriele; Scorrano, Luca; Giacomello, Marta; Montopoli, Monica
Correction: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy (Cell Death & Disease, (2022), 13, 4, (398), 10.1038/s41419-022-04741-9) 1-gen-2022 Vianello, C.; Cocetta, V.; Catanzaro, D.; Dorn, G. W.; De Milito, A.; Rizzolio, F.; Canzonieri, V.; Cecchin, E.; Roncato, R.; Toffoli, G.; Quagliariello, V.; Di Mauro, A.; Losito, S.; Maurea, N.; Cono, S.; Sales, G.; Scorrano, L.; Giacomello, M.; Montopoli, M.
An Integrated Pharmacological Counselling Approach to Guide Decision-Making in the Treatment with CDK4/6 Inhibitors for Metastatic Breast Cancer 1-gen-2022 Roncato, R.; Gerratana, L.; Palmero, L.; Gagno, S.; Poetto, A. S.; Peruzzi, E.; Zanchetta, M.; Posocco, B.; De Mattia, E.; Canil, G.; Alberti, M.; Orleni, M.; Toffoli, G.; Puglisi, F.; Cecchin, E.
Lipid rafts as viral entry routes and immune platforms: A double-edged sword in SARS-CoV-2 infection? 1-gen-2022 Roncato, Rossana; Angelini, Jacopo; Pani, Arianna; Talotta, Rossella
Rare genetic variant burden in DPYD predicts severe fluoropyrimidine-related toxicity risk 1-gen-2022 De Mattia, E.; Silvestri, M.; Polesel, J.; Ecca, F.; Mezzalira, S.; Scarabel, L.; Zhou, Y.; Roncato, R.; Lauschke, V. M.; Calza, S.; Spina, M.; Puglisi, F.; Toffoli, G.; Cecchin, E.
European association for clinical pharmacology and therapeutics young clinical pharmacologists working group: a cornerstone for the brighter future of clinical pharmacology 1-gen-2022 Belančić, Andrej; Sans-Pola, Carla; Jouanjus, Emilie; Alcubilla, Pau; Arellano, Ana Lucía; Žunić, Miodrag; Nogueiras-Álvarez, Rita; Roncato, Rossana; Sáez-Peñataro, Joaquín
A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study 1-gen-2023 Swen, Jesse J; van der Wouden, Cathelijne H; Manson, Lisanne En; Abdullah-Koolmees, Heshu; Blagec, Kathrin; Blagus, Tanja; Böhringer, Stefan; Cambon-Thomsen, Anne; Cecchin, Erika; Cheung, Ka-Chun; Deneer, Vera Hm; Dupui, Mathilde; Ingelman-Sundberg, Magnus; Jonsson, Siv; Joefield-Roka, Candace; Just, Katja S; Karlsson, Mats O; Konta, Lidija; Koopmann, Rudolf; Kriek, Marjolein; Lehr, Thorsten; Mitropoulou, Christina; Rial-Sebbag, Emmanuelle; Rollinson, Victoria; Roncato, Rossana; Samwald, Matthias; Schaeffeler, Elke; Skokou, Maria; Schwab, Matthias; Steinberger, Daniela; Stingl, Julia C; Tremmel, Roman; Turner, Richard M; van Rhenen, Mandy H; Dávila Fajardo, Cristina L; Dolžan, Vita; Patrinos, George P; Pirmohamed, Munir; Sunder-Plassmann, Gere; Toffoli, Giuseppe; Guchelaar, Henk-Jan
Implementation of preemptive testing of a pharmacogenomic panel in clinical practice: Where do we stand? 1-gen-2023 Peruzzi, Elena; Roncato, Rossana; De Mattia, Elena; Bignucolo, Alessia; Swen, Jesse J; Guchelaar, Henk-Jan; Toffoli, Giuseppe; Cecchin, Erika
Clinical impact of body mass index on palbociclib treatment outcomes and effect on exposure 1-gen-2023 Roncato, R.; Peruzzi, E.; Gerratana, L.; Posocco, B.; Nuzzo, S.; Montico, M.; Orleni, M.; Corsetti, S.; Bartoletti, M.; Gagno, S.; Canil, G.; De Mattia, E.; Angelini, J.; Baraldo, M.; Puglisi, F.; Cecchin, E.; Toffoli, G.
Impact of ABCG2 and ABCB1 Polymorphisms on Imatinib Plasmatic Exposure: An Original Work and Meta-Analysis 1-gen-2023 Dalle Fratte, Chiara; Polesel, Jerry; Gagno, Sara; Posocco, Bianca; De Mattia, Elena; Roncato, Rossana; Orleni, Marco; Puglisi, Fabio; Guardascione, Michela; Buonadonna, Angela; Toffoli, Giuseppe; Cecchin, Erika
CYP2D6 and CYP2C8 pharmacogenetics and pharmacological interactions to predict imatinib plasmatic exposure in GIST patients 1-gen-2023 Dalle Fratte, C.; Gagno, S.; Roncato, R.; Polesel, J.; Zanchetta, M.; Buzzo, M.; Posocco, B.; De Mattia, E.; Borsatti, R.; Puglisi, F.; Foltran, L.; Guardascione, M.; Buonadonna, A.; Cecchin, E.; Toffoli, G.
Cost-utility analysis and cross-country comparison of pharmacogenomics-guided treatment in colorectal cancer patients participating in the U-PGx PREPARE study 1-gen-2023 Fragoulakis, Vasileios; Roncato, Rossana; Bignucolo, Alessia; Patrinos, George P.; Toffoli, Giuseppe; Cecchin, Erika; Mitropoulou, Christina
The burden of rare variants in DPYS gene is a novel predictor of the risk of developing severe fluoropyrimidine-related toxicity 1-gen-2023 De Mattia, E.; Polesel, J.; Silvestri, M.; Roncato, R.; Scarabel, L.; Calza, S.; Spina, M.; Puglisi, F.; Toffoli, G.; Cecchin, E.
The use of therapeutic drug monitoring to highlight an over-looked drug-drug interaction leading to imatinib treatment failure 1-gen-2023 Gagno, Sara; Buonadonna, Angela; Dalle Fratte, Chiara; Guardascione, Michela; Zanchetta, Martina; Posocco, Bianca; Orleni, Marco; Canil, Giovanni; Roncato, Rossana; Cecchin, Erika; Toffoli, Giuseppe
Ten-year experience with pharmacogenetic testing for DPYD in a national cancer center in Italy: Lessons learned on the path to implementation 1-gen-2023 Bignucolo, A; De Mattia, E; Roncato, R; Peruzzi, E; Scarabel, L; D'Andrea, M; Sartor, F; Toffoli, G; Cecchin, E
Association of ADME gene polymorphisms on toxicity to CDK4/6 inhibitors in patients with HR+ HER2- metastatic breast cancer 1-gen-2023 Peruzzi, Elena; Gerratana, Lorenzo; Montico, Marcella; Posocco, Bianca; Corsetti, Serena; Bartoletti, Michele; Gagno, Sara; Orleni, Marco; De Mattia, Elena; Baraldo, Massimo; Cecchin, Erika; Puglisi, Fabio; Toffoli, Giuseppe; Roncato, Rossana
LC-MS/MS Method for the Quantification of PARP Inhibitors Olaparib, Rucaparib and Niraparib in Human Plasma and Dried Blood Spot: Development, Validation and Clinical Validation for Therapeutic Drug Monitoring 1-gen-2023 Canil, Giovanni; Orleni, Marco; Posocco, Bianca; Gagno, Sara; Bignucolo, Alessia; Montico, Marcella; Roncato, Rossana; Corsetti, Serena; Bartoletti, Michele; Toffoli, Giuseppe
Unlocking the potential of Molecular Tumor Boards: from cutting-edge data interpretation to innovative clinical pathways 1-gen-2024 Pasto, B.; Buzzatti, G.; Schettino, C.; Malapelle, U.; Bergamini, A.; De Angelis, C.; Musacchio, L.; Dieci, M. V.; Kuhn, E.; Lambertini, M.; Passarelli, A.; Toss, A.; Farolfi, A.; Roncato, R.; Capoluongo, E.; Vida, R.; Pignata, S.; Callari, M.; Baldassarre, G.; Bartoletti, M.; Gerratana, L.; Puglisi, F.
Quantification of Letrozole, Palbociclib, Ribociclib, Abemaciclib, and Metabolites in Volumetric Dried Blood Spots: Development and Validation of an LC-MS/MS Method for Therapeutic Drug Monitoring 1-gen-2024 Cecchin, Eleonora; Orleni, Marco; Gagno, Sara; Montico, Marcella; Peruzzi, Elena; Roncato, Rossana; Gerratana, Lorenzo; Corsetti, Serena; Puglisi, Fabio; Toffoli, Giuseppe; Cecchin, Erika; Posocco, Bianca
Mostrati risultati da 1 a 50 di 55
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