Purpose. To investigate the effect of the combination of photodynamic therapy with verteporfin and subconjunctival bevacizumab and triamcinolone acetonide on corneal neovascularization secondary to corneal graft failure. Methods. A patient with extensive deep and superficial corneal neovascularization underwent same day triple therapy with subconjunctival bevacizumab (1.25 mg), subconjunctival triamcinolone acetonide (40 mg), and photodynamic therapy with verteporfin (fluence 50 J/cm 2, irradiance 300 mW/cm 2). Results. A complete angiographic new vessel regression was obtained and was discernible starting 7 days after combination therapy. Three months after treatment, an initial new-vessel sprout was noted. Triple therapy was then repeated. No angiographic evidence of corneal neovascularization was detectable for the entire 6-month follow-up duration. Conclusions. Triple therapy may offer a promising tool in the treatment of corneal neovascularization. © 2011 Wichtig Editore.

Triple therapy for corneal neovascularization: A case report

VERITTI, Daniele;LANZETTA, Paolo
2012-01-01

Abstract

Purpose. To investigate the effect of the combination of photodynamic therapy with verteporfin and subconjunctival bevacizumab and triamcinolone acetonide on corneal neovascularization secondary to corneal graft failure. Methods. A patient with extensive deep and superficial corneal neovascularization underwent same day triple therapy with subconjunctival bevacizumab (1.25 mg), subconjunctival triamcinolone acetonide (40 mg), and photodynamic therapy with verteporfin (fluence 50 J/cm 2, irradiance 300 mW/cm 2). Results. A complete angiographic new vessel regression was obtained and was discernible starting 7 days after combination therapy. Three months after treatment, an initial new-vessel sprout was noted. Triple therapy was then repeated. No angiographic evidence of corneal neovascularization was detectable for the entire 6-month follow-up duration. Conclusions. Triple therapy may offer a promising tool in the treatment of corneal neovascularization. © 2011 Wichtig Editore.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11390/1021158
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