Purpose. To investigate the effect of the combination of photodynamic therapy with verteporfin and subconjunctival bevacizumab and triamcinolone acetonide on corneal neovascularization secondary to corneal graft failure. Methods. A patient with extensive deep and superficial corneal neovascularization underwent same day triple therapy with subconjunctival bevacizumab (1.25 mg), subconjunctival triamcinolone acetonide (40 mg), and photodynamic therapy with verteporfin (fluence 50 J/cm 2, irradiance 300 mW/cm 2). Results. A complete angiographic new vessel regression was obtained and was discernible starting 7 days after combination therapy. Three months after treatment, an initial new-vessel sprout was noted. Triple therapy was then repeated. No angiographic evidence of corneal neovascularization was detectable for the entire 6-month follow-up duration. Conclusions. Triple therapy may offer a promising tool in the treatment of corneal neovascularization. © 2011 Wichtig Editore.

Triple therapy for corneal neovascularization: A case report

VERITTI, Daniele;LANZETTA, Paolo
2012

Abstract

Purpose. To investigate the effect of the combination of photodynamic therapy with verteporfin and subconjunctival bevacizumab and triamcinolone acetonide on corneal neovascularization secondary to corneal graft failure. Methods. A patient with extensive deep and superficial corneal neovascularization underwent same day triple therapy with subconjunctival bevacizumab (1.25 mg), subconjunctival triamcinolone acetonide (40 mg), and photodynamic therapy with verteporfin (fluence 50 J/cm 2, irradiance 300 mW/cm 2). Results. A complete angiographic new vessel regression was obtained and was discernible starting 7 days after combination therapy. Three months after treatment, an initial new-vessel sprout was noted. Triple therapy was then repeated. No angiographic evidence of corneal neovascularization was detectable for the entire 6-month follow-up duration. Conclusions. Triple therapy may offer a promising tool in the treatment of corneal neovascularization. © 2011 Wichtig Editore.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11390/1021158
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