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Facial reanimation in radical parotidectomy: The Milan proposal

Surgery for advanced stage or recurrent parotid tumors often involves VII nerve sacrifice. Facial reanimation techniques aim to restore corneal protection and both static and dynamic facial symmetry, without compromising resection. Surgical strategies were based on tumor histology and intraoperative frozen section analysis. Masseteric to facial nerve branch (for the ZMM) neurorrhaphy was done in patients without perineural invasion, while temporalis muscle tendon lengthening was used when tha...

A practical clinical approach to the diagnosis and management of morphea (localized scleroderma)

Morphea, also referred to as localized cutaneous scleroderma, encompasses a heterogeneous group of inflammatory and fibrosing skin disorders characterized by variable depth of tissue involvement and different clinical course. The diagnostic delay remains common due to insidious onset, broad differential diagnosis, and lack of validated biomarkers of disease activity. Clinical assessment relies therefore on expert evaluation, supported by clinical scoring systems and selected imaging technique...

From Environmental Risk to Cancer Stemness: Epigenetic Regulation in Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) represents a major global health burden and remains one of the most prevalent and aggressive malignancies of the head and neck region. Despite significant advances in surgical techniques, chemotherapy, and radiotherapy, patient outcomes have improved only modestly over recent decades. The high recurrence rate, metastatic potential, and resistance to therapy underscore the complexity of OSCC biology and the limitations of conventional treatment approaches. I...

The Role of Internal Medicine or Hospitalist Co-Management in Surgical Specialties: Implications for Adult and Elderly Plastic Surgery Patients

Background and Objectives: Patients admitted to plastic surgery units increasingly present with multimorbidity, advanced age, diabetes, cardiovascular disease, chronic wounds, and complex metabolic requirements. In several surgical specialties, internal medicine specialist (IMS) co-management has been associated with improved clinical outcomes, yet its potential role in plastic surgery remains unexplored. Materials and Methods: A narrative scoping review conducted using systematic search prin...

Comparative effectiveness and predictors of remission between adalimumab and ixekizumab in patients with psoriatic arthritis: findings from the 'AIRE' multicentre study

BACKGROUND: Tumour necrosis factor α (TNFi) and interleukin 17 (IL-17) inhibitors have demonstrated efficacy and safety in psoriatic arthritis (PsA) therapy through head-to-head randomised controlled trials, but evidence from real-world clinical practice (RWE) remains limited. METHODS: Adalimumab vs Ixekizumab Real-world Effectiveness is a multicentre cohort study, aimed at comparing the effectiveness of these drugs in a 'real-world' PsA population. The primary outcome consisted of mixed-effe...

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