1 Contributo su Rivista

1 Contributo su Rivista: [49394] Home page macrotipologia

Sfoglia

Prodotti recenti

Perspectives of Italian lay persons who would decline genetic risk information: “I think I'd be living in constant worry”

This study explores lay public perspectives on intrafamilial genetic risk communication, focusing on individuals who hypothetically choose not to receive genetic information, a largely overlooked population in genetic counseling research. A nested cross-sectional online survey combining both closed- and open-ended questions was used. Quantitative data included sociodemographic characteristics, family functioning as measured with the SCORE-15, genetic literacy (score range 0–4), and preference...

Tumor Involvement of the Nipple at Preoperative Contrast-enhanced Mammography: A Multicenter Diagnostic Accuracy Study

Background Assessing nipple involvement in breast cancer at preoperative imaging is crucial for nipple-preserving surgery, but no studies have investigated the utility of contrast-enhanced mammography (CEM) in this assessment. Purpose To evaluate the diagnostic accuracy of CEM in ruling in pathologic nipple involvement and identify associated CEM features. Materials and Methods This retrospective multicenter study included patients with biopsy-proven breast cancer treated with primary surgery...

Iatrogenic NORSE: Immune checkpoint inhibitor-related anti-GFAP autoimmune astrocytopathy

Immune checkpoint inhibitors (ICIs) have radically improved cancer therapy but are associated with a spectrum of immune-related adverse events (irAEs), including infrequent (1–3 %) neurological complications. Pembrolizumab, an anti-PD-1 monoclonal antibody, enhances antitumor immunity but may disrupt self-tolerance, leading to autoimmune phenomena. This case report describes a patient with triple metachronous malignancies (cerebral hemangioblastoma, clear cell renal carcinoma, and non-small c...

Influence of Coffee Roasting Degree from Four Mexican Regions on In Vitro Antioxidant Activity and Digestive Enzyme Inhibition and Its In Vivo Effects on Carbohydrate and Lipid Absorption

Coffee is among the most consumed beverages worldwide and is recognized for its bioactive compounds, which exert diverse physiological effects. This study evaluated the impact of roasting degree on the in vitro antioxidant activity and digestive enzyme inhibition of brews from four Mexican regions, as well as their in vivo effects on carbohydrate and lipid absorption. Antioxidant capacity was assessed through radical scavenging and lipid peroxidation inhibition, while inhibition of lipase, α-...

Vitamin D intake in Italian healthy subjects and patients with different pathological disorders

Background: Vitamin D deficiency is recognized as a widespread public health issue, particularly among individuals with limited sun exposure or chronic diseases. While cutaneous synthesis provides most vitamin D, dietary sources remain essential, particularly in populations with restricted outdoor activity or poor dietary habits. Methods: This cross-sectional study evaluated dietary vitamin D intake in 1,372 Italian adults (997 females, 375 males; aged 40–80 years) using a validated 14-day Fo...

Scopri

Accesso al fulltext

no fulltext26277
reserved14694
open7831
partially open450
restricted128
embargoed10
mixed4