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International expert consensus on the clinical integration of circulating tumor cells in solid tumors

Background Circulating tumor cells (CTCs) are a versatile biomarker in solid tumors. Extensive research supports their clinical relevance and led to regulatory approval in breast, prostate, and colorectal cancers. However, clinical adoption remains limited mainly due to the lack of consensus and standardized technologies. Additionally, CTC research lacks unified direction. To address these gaps, an international expert panel was established to assess the current and future clinical utility of...

End Points for the Next-Generation Bladder-Sparing Perioperative Trials for Patients With Muscle-Invasive Bladder Cancer

PURPOSE: The evolving treatment landscape of muscle-invasive bladder cancer (MIBC) increasingly warrants novel trial design to evaluate perioperative strategies aimed at bladder preservation. To establish standardized outcome measures for evaluating organ preservation strategies in MIBC, the International Bladder Cancer Group (IBCG) and the Global Society of Rare Genitourinary Tumors (GSRGT) assembled an international, multidisciplinary consensus panel. METHODS: The IBCG and GSRGT gathered gl...

The role of bioimpedance in determining protein intake after ICU care

Nutrition in critically ill patients after intensive care unit (ICU) discharge is frequently omitted and still poorly investigated. Patients during ICU stay experience great muscle loss that is the main cause of ICU-acquired weakness with consequent physical disability, including difficult eating. Moreover, ICU survivors have an altered nutritional status, may present dysphagia, taste alterations and mood disorders which in turn could aggravate malnutrition. For this purpose, body composition...

Tailor-made protein-rich bread for the elderly: integrating sensory preferences with nutritional and technological goals

This study aimed to evaluate the mechanical and sensory characteristics of a functional bread, and secondarily examined the attitudes and consumption habits of elderly people toward legumes to assess the potential acceptance of pea protein–based bread in this group. Experimental breads were made by replacing 5% of wheat flour with pea protein concentrate, either untreated or processed via high-pressure homogenization. The breads showed a homemade, heterogeneous appearance, which was appreciat...

Caratterizzazione microbiologica di polvere di cacao e di cioccolato del commercio [Microbial characterization of retail cacao powders and chocolate bars]

A microbial characterization was performed in cocoa powder and chocolate bars of three batches of 5 different brands marketed in Italian supermarkets. The results showed a variable microbial population consisting of mesophilic and thermophilic spore-forming in both types of products. The chocolate bars were also contaminated with molds of environmental origin. The spores mainly originate from the raw materials, the cocoa beans, as the heat treatments involved (roasting of the beans and conchi...

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