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Biotope-dependent resistance to reactive oxygen species, antibiotic tolerance, and virulence of Staphylococcus aureus

The human and livestock pathogen Staphylococcus aureus poses a major clinical challenge due to antibiotic treatment failure. Its resilience is mainly attributed to antibiotic resistance and tolerance mechanisms related to persistence. Here we investigate how two infection-relevant conditions, milk and serum, shape S. aureus pathogenic properties and capacity to withstand environmental stresses. Milk- versus serum-grown bacteria show gross differences in envelope physical properties, membrane ...

Architecture in painted space: reconstructions for tactile translation

The spread of practices and devices designed to make cultural heritage accessible has expanded the possibilities for bringing blind and visually impaired people into contact with works of art through reliefs, bas-reliefs, and three-dimensional models. In painting, however, tactile translation poses specific challenges, especially when understanding the work depends on the perspectival construction of space: transposing only the outline into relief makes figures ...

Vulnerability detection in Solidity smart contracts via machine learning: A qualitative analysis

Smart contracts are central to most blockchain applications, from financial transactions to supply chain management. However, their adoption is hindered by security vulnerabilities that can result in significant financial losses. Most vulnerability detection tools and methods available nowadays leverage either static analysis methods or machine learning. Unfortunately, as valuable as they are, both approaches suffer from limitations that make them only partially effective. In this survey, we ...

Shorter is not always better: Stroke unit length of stay and outcomes after acute ischemic stroke

Background and objective: Stroke Unit (SU) care is a cornerstone of acute ischemic stroke (AIS) management, yet typically conceptualized as a binary exposure. The prognostic impact of SU length of stay variability remains unclear. We investigated the association between SU length of stay and outcomes in AIS patients, exploring whether its determinants carry implications for stroke care organization. Methods: Retrospective analysis of a prospective single-center register of consecutive AIS pat...

Post-mortem human brain evidence for presynaptic dopaminergic dysregulation in cocaine use disorder: A systematic review

Cocaine use disorder (CUD) is associated with dopaminergic abnormalities, but post-mortem evidence has not clarified whether molecular changes preferentially involve presynaptic dopamine regulation rather than broader monoaminergic alterations. We conducted a PRISMA 2020 systematic review of post-mortem case-control studies comparing individuals with CUD versus controls and quantifying dopaminergic, serotonergic, or noradrenergic markers using molecular, transcriptional, or ligand-binding mea...

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