Oligometastatic NSCLC: Current Perspectives and Future Challenges

Oligometastatic non-small cell lung cancer (NSCLC) represents a separate entity with a different biology and prognosis compared to stage IV NSCLC. Challenges range from the very definition of oligometastatic disease to the timing and techniques of local treatments, and their benefit in prolonging patient survival. Most of the international consensus and guidelines agree on the need for shared criteria, such as appropriate stadiation and even tissue biopsy if needed, in order to select patient...

CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors

Background: Adaptive human natural killer (NK) cells are an NK cell subpopulation arising upon cytomegalovirus (CMV) infection. They are characterized by CD94/NKG2C expression, a mature CD57+KIR+NKG2A– phenotype, a prolonged lifespan, and remarkable antitumor functions. In light of these features, adaptive NK cells represent suitable candidate to design next-generation therapies, based on their enhanced effector function which could be further boosted by Chimeric Antigen Receptors-engineering...

Chain of thought reasoning in enhancing infectious disease diagnosis and microbiological analysis

Part 2—Cardiac Rehabilitation After an Acute Myocardial Infarction: Timing and Gender Differences in Adherence; Where Do We Stand?

Cardiac rehabilitation is a beneficial multidisciplinary interventional protocol that improves cardiovascular health and reduces mortality and morbidity rates in patients with cardiovascular diseases. Multiple studies have demonstrated that the implementation of such protocols in patients with acute myocardial infarction (MI) dramatically improved patients’ outcome. It is unfortunate that in practice, in spite of the advantages of cardiac rehabilitation, this approach is seldom employed. Inde...