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EnglishObjectives To assess a group of adolescents with bronchopulmonary dysplasia (BPD) from a biochemical-metabolic standpoint, applying the metabolomic approach to studying their exhaled breath condensate (EBC). Study design Twenty adolescents with BPD (mean age 14.8 years) and 15 healthy controls (mean age 15.2 years) were recruited for EBC collection, exhaled nitric oxide measurement, and spirometry. The EBC samples were analyzed using a metabolomic approach based on mass spectrometry. The obtained spectra were analyzed using multivariate statistical analysis tools. Results A reliable Orthogonal Projections to Latent Structures-Discriminant Analysis model showed a clear discrimination between cases of BPD and healthy controls (R-2 = 0.95 and Q(2) = 0.92). The search for putative biomarkers identified an altered complex lipid profile in the adolescents with BPD. Conclusions The metabolomic analysis of EBC distinguishes cases of BPD from healthy individuals, suggesting that the lung of survivors of BPD is characterized by long-term metabolic abnormalities. The search for putative biomarkers indicated a possible role of an altered surfactant composition, which may persist far beyond infancy
Airway metabolic anomalies in adolescents with bronchopulmonary dysplasia: new insights from the metabolomic approach / Carraro, S.; Giordano, G.; Pirillo, P.; Maretti, M.; Reniero, F.; Cogo, P.; Perilongo, G.; Stocchero, M.; Baraldi, E.. - In: JOURNAL OF PEDIATRICS. - ISSN 0022-3476. - ELETTRONICO. - 166:2(2015), pp. 234-239.
| Titolo: | Airway metabolic anomalies in adolescents with bronchopulmonary dysplasia: new insights from the metabolomic approach |
| Autori: | |
| Data di pubblicazione: | 2015 |
| Rivista: | |
| Citazione: | Airway metabolic anomalies in adolescents with bronchopulmonary dysplasia: new insights from the metabolomic approach / Carraro, S.; Giordano, G.; Pirillo, P.; Maretti, M.; Reniero, F.; Cogo, P.; Perilongo, G.; Stocchero, M.; Baraldi, E.. - In: JOURNAL OF PEDIATRICS. - ISSN 0022-3476. - ELETTRONICO. - 166:2(2015), pp. 234-239. |
| Abstract: | Objectives To assess a group of adolescents with bronchopulmonary dysplasia (BPD) from a biochemical-metabolic standpoint, applying the metabolomic approach to studying their exhaled breath condensate (EBC). Study design Twenty adolescents with BPD (mean age 14.8 years) and 15 healthy controls (mean age 15.2 years) were recruited for EBC collection, exhaled nitric oxide measurement, and spirometry. The EBC samples were analyzed using a metabolomic approach based on mass spectrometry. The obtained spectra were analyzed using multivariate statistical analysis tools. Results A reliable Orthogonal Projections to Latent Structures-Discriminant Analysis model showed a clear discrimination between cases of BPD and healthy controls (R-2 = 0.95 and Q(2) = 0.92). The search for putative biomarkers identified an altered complex lipid profile in the adolescents with BPD. Conclusions The metabolomic analysis of EBC distinguishes cases of BPD from healthy individuals, suggesting that the lung of survivors of BPD is characterized by long-term metabolic abnormalities. The search for putative biomarkers indicated a possible role of an altered surfactant composition, which may persist far beyond infancy |
| Handle: | http://hdl.handle.net/11390/1071329 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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| File | Descrizione | Tipologia | Licenza | |
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| Airway Metabolic Anomalies in Adolescents with Bronchopulmonary - Journal of pediatrics 2015.pdf | Versione Editoriale (PDF) | Non pubblico | Accesso ristretto Richiedi una copia |
http://hdl.handle.net/11390/1071329
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