It is well established that full activation of T cells to recognize a specific antigen requires additional signals. These secondary signals are generated by the interaction of costimulatory molecules expressed on APCs. Classical APCs include DCs, macrophages, Langerhans cells, and B cells. However, in recent years, several haematopoietic and nonhaematopoietic cells have been described to express MHC class II antigens and, in appropriate conditions, costimulatory molecules. In this issue, Suurmond et al. [Eur. J. Immunol. 2016. 46: 1132-1141] show, for the first time, that human mast cells not only express costimulatory molecules of the TNF-receptor and CD28 families, but can also costimulate T cells through a yet-to-be-defined CD28-independent interaction.

Deciphering new mechanisms on T-cell costimulation by human mast cells

FROSSI, Barbara;Mion, Francesca;PUCILLO, Carlo Ennio Michele
2016

Abstract

It is well established that full activation of T cells to recognize a specific antigen requires additional signals. These secondary signals are generated by the interaction of costimulatory molecules expressed on APCs. Classical APCs include DCs, macrophages, Langerhans cells, and B cells. However, in recent years, several haematopoietic and nonhaematopoietic cells have been described to express MHC class II antigens and, in appropriate conditions, costimulatory molecules. In this issue, Suurmond et al. [Eur. J. Immunol. 2016. 46: 1132-1141] show, for the first time, that human mast cells not only express costimulatory molecules of the TNF-receptor and CD28 families, but can also costimulate T cells through a yet-to-be-defined CD28-independent interaction.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11390/1083581
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