Background: Limited data are available on the prognostic performance of Adjuvant! Online (AOL) and Nottingham Prognostic Index (NPI) in young breast cancer patients. Methods: This multicentre hospital-based retrospective cohort study included young (p40 years) and older (55–60 years) breast cancer patients treated from January 2000 to December 2004 at four large Belgian and Italian institutions. Predicted 10-year overall survival (OS) and disease-free survival (DFS) using AOL and 10-year OS using NPI were calculated for every patient. Tools ability to predict outcomes (i.e., calibration) and their discriminatory accuracy was assessed. Results: The study included 1283 patients, 376 young and 907 older women. Adjuvant! Online accurately predicted 10-year OS (absolute difference: 0.7%; P¼0.37) in young cohort, but overestimated 10-year DFS by 7.7% (P¼0.003). In older cohort, AOL significantly underestimated both 10-year OS and DFS by 7.2% (Po0.001) and 3.2% (P¼0.04), respectively. Nottingham Prognostic Index significantly underestimated 10-year OS in both young (8.5%; Po0.001) and older (4.0%; Po0.001) cohorts. Adjuvant! Online and NPI had comparable discriminatory accuracy. Conclusions: In young breast cancer patients,

The prognostic performance of Adjuvant! Online and Nottingham Prognostic Index in young breast cancer patients

PUGLISI, Fabio;
2016-01-01

Abstract

Background: Limited data are available on the prognostic performance of Adjuvant! Online (AOL) and Nottingham Prognostic Index (NPI) in young breast cancer patients. Methods: This multicentre hospital-based retrospective cohort study included young (p40 years) and older (55–60 years) breast cancer patients treated from January 2000 to December 2004 at four large Belgian and Italian institutions. Predicted 10-year overall survival (OS) and disease-free survival (DFS) using AOL and 10-year OS using NPI were calculated for every patient. Tools ability to predict outcomes (i.e., calibration) and their discriminatory accuracy was assessed. Results: The study included 1283 patients, 376 young and 907 older women. Adjuvant! Online accurately predicted 10-year OS (absolute difference: 0.7%; P¼0.37) in young cohort, but overestimated 10-year DFS by 7.7% (P¼0.003). In older cohort, AOL significantly underestimated both 10-year OS and DFS by 7.2% (Po0.001) and 3.2% (P¼0.04), respectively. Nottingham Prognostic Index significantly underestimated 10-year OS in both young (8.5%; Po0.001) and older (4.0%; Po0.001) cohorts. Adjuvant! Online and NPI had comparable discriminatory accuracy. Conclusions: In young breast cancer patients,
File in questo prodotto:
File Dimensione Formato  
Lambertini M et al_Puglisi__British Journal Cancer 2016.pdf

non disponibili

Tipologia: Versione Editoriale (PDF)
Licenza: Non pubblico
Dimensione 508.95 kB
Formato Adobe PDF
508.95 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11390/1092030
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 40
  • ???jsp.display-item.citation.isi??? 40
social impact