Objectives: Prevalence of vulvar-vaginal atrophy (VVA) has been always investigated by phone or webinterview without any objective evaluation. Objective signs associated with symptoms of VVA are nowtermed genitourinary syndrome of menopause (GSM). This multi-centric study was performed in orderto provide nation-wide data on the prevalence and management of GSM.Methods: Nine hundred thirteen females, 59.3 ± 7.4 years old asking for a routine gynecological examina-tion were recruited. Diagnosis of GSM was based on patient sensation of vaginal dryness, any objectivesign of VVA and a pH > 5.Results: A 722/913 (79.1%) women were diagnosed with GSM with a prevalence ranging from 64.7% to84.2%, starting from 1 to 6 years after menopause. Sedentary women were at higher risk of GSM (OR 1.8,95% CI: 1.3–2.5; p = 0.0005). Recent vaginal infection was more likely in women with GSM (OR 2.48, 95% CI:1.33–4.62; p = 0.0041). Symptoms reported by women with GSM were vaginal dryness (100%), dyspare-unia (77.6%), burning (56.9%), itching (56.6%) and dysuria (36.1%). Signs detected by gynecologists weremucosal dryness (99%), thinning of vaginal rugae (92.1%), pallor of the mucosa (90.7%), mucosal fragility(71.9%) and petechiae (46.7%). Only 274 (30%) of women had had a previous diagnosis of VVA/GSM.These were treated either with no therapy (9.8%), systemic hormone (9.2%), local hormone (44.5%) orlocal non-hormonal (36.5%) therapy. At the time of our investigation 266 of them (97.1%) still had thedisorder.Conclusions: GSM is a common, under-diagnosed and under-treated disorder. Measures to improve itsearly detection and its appropriate management are needed.

Vaginal atrophy of women in postmenopause. Results from amulticentric observational study: The AGATA study

CAGNACCI, Angelo
2016

Abstract

Objectives: Prevalence of vulvar-vaginal atrophy (VVA) has been always investigated by phone or webinterview without any objective evaluation. Objective signs associated with symptoms of VVA are nowtermed genitourinary syndrome of menopause (GSM). This multi-centric study was performed in orderto provide nation-wide data on the prevalence and management of GSM.Methods: Nine hundred thirteen females, 59.3 ± 7.4 years old asking for a routine gynecological examina-tion were recruited. Diagnosis of GSM was based on patient sensation of vaginal dryness, any objectivesign of VVA and a pH > 5.Results: A 722/913 (79.1%) women were diagnosed with GSM with a prevalence ranging from 64.7% to84.2%, starting from 1 to 6 years after menopause. Sedentary women were at higher risk of GSM (OR 1.8,95% CI: 1.3–2.5; p = 0.0005). Recent vaginal infection was more likely in women with GSM (OR 2.48, 95% CI:1.33–4.62; p = 0.0041). Symptoms reported by women with GSM were vaginal dryness (100%), dyspare-unia (77.6%), burning (56.9%), itching (56.6%) and dysuria (36.1%). Signs detected by gynecologists weremucosal dryness (99%), thinning of vaginal rugae (92.1%), pallor of the mucosa (90.7%), mucosal fragility(71.9%) and petechiae (46.7%). Only 274 (30%) of women had had a previous diagnosis of VVA/GSM.These were treated either with no therapy (9.8%), systemic hormone (9.2%), local hormone (44.5%) orlocal non-hormonal (36.5%) therapy. At the time of our investigation 266 of them (97.1%) still had thedisorder.Conclusions: GSM is a common, under-diagnosed and under-treated disorder. Measures to improve itsearly detection and its appropriate management are needed.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11390/1105869
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