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EnglishThe role of progestogens in Hormone Replacement Therapy (HRT) is to counteract the estrogen- dependent endometrial mitotic stimulation, thus significantly reducing hyperplasia/carcinoma risk of endometrial cells. Progestogens are different for pharmacological potency, secondary effects on other receptors than progestin receptor, and metabolic effect on various tissues (e.g., breast) and systems (e.g., cardiovascular, central nervous system) of the women’s body. This review summarizes current data on progestogen’s pharmacological role in HRT use for menopause management
| Titolo: | Progestin compounds in hormone replacemnt therapy |
| Autori: | |
| Data di pubblicazione: | 2013 |
| Rivista: | |
| Citazione: | Progestin compounds in hormone replacemnt therapy / Neri Manuela; Cornacchia Stefania; Orrù Marisa; Corda Valentina; Malune Maria Elena; D'Alterio MAurizio Nicola; Lello Stefano; Capozzi Anna; Cagnacci Angelo; Di Carlo Costantino; Melis Gina Benedetto; Paoletti Anna Maria. - In: MULTIDISCIPLINARY JOURNAL OF WOMEN'S HEALTH.. - ISSN 2281-3403. - STAMPA. - 2(2013), pp. 44-49. |
| Abstract: | The role of progestogens in Hormone Replacement Therapy (HRT) is to counteract the estrogen- dependent endometrial mitotic stimulation, thus significantly reducing hyperplasia/carcinoma risk of endometrial cells. Progestogens are different for pharmacological potency, secondary effects on other receptors than progestin receptor, and metabolic effect on various tissues (e.g., breast) and systems (e.g., cardiovascular, central nervous system) of the women’s body. This review summarizes current data on progestogen’s pharmacological role in HRT use for menopause management |
| Handle: | http://hdl.handle.net/11390/1105870 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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