The role of progestogens in Hormone Replacement Therapy (HRT) is to counteract the estrogen- dependent endometrial mitotic stimulation, thus significantly reducing hyperplasia/carcinoma risk of endometrial cells. Progestogens are different for pharmacological potency, secondary effects on other receptors than progestin receptor, and metabolic effect on various tissues (e.g., breast) and systems (e.g., cardiovascular, central nervous system) of the women’s body. This review summarizes current data on progestogen’s pharmacological role in HRT use for menopause management

Progestin compounds in hormone replacemnt therapy / Neri Manuela; Cornacchia Stefania; Orrù Marisa; Corda Valentina; Malune Maria Elena; D'Alterio MAurizio Nicola; Lello Stefano; Capozzi Anna; Cagnacci Angelo; Di Carlo Costantino; Melis Gina Benedetto; Paoletti Anna Maria. - In: MULTIDISCIPLINARY JOURNAL OF WOMEN'S HEALTH.. - ISSN 2281-3403. - STAMPA. - 2(2013), pp. 44-49.

Progestin compounds in hormone replacemnt therapy

CAGNACCI, Angelo;
2013

Abstract

The role of progestogens in Hormone Replacement Therapy (HRT) is to counteract the estrogen- dependent endometrial mitotic stimulation, thus significantly reducing hyperplasia/carcinoma risk of endometrial cells. Progestogens are different for pharmacological potency, secondary effects on other receptors than progestin receptor, and metabolic effect on various tissues (e.g., breast) and systems (e.g., cardiovascular, central nervous system) of the women’s body. This review summarizes current data on progestogen’s pharmacological role in HRT use for menopause management
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11390/1105870
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