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EnglishThe genetic predisposition to a long-term efficacy of anti-tumor necrosis factor (TNF)alpha treatment in seronegative spondyloarthritis (SpA) was investigated by analysing the possible correlation between several single nucleotide gene polymorphisms and the retention rate of anti-TNF alpha therapies. We compared patients needing to switch the first anti-TNF alpha (Sw, No. 64) within at least 12 months of follow-up with patients not needing to switch (NSw, No. 123), observing at least 6 months of treatment to establish anti-TNF alpha failure, leading to treatment change. Response to treatment was evaluated by standardised criteria (BASDAI for axial involvement, DAS28-EULAR for peripheral involvement). The TNF alpha -308 A allele and the interleukin (IL)-6 -174GG homozygosis resulted as independent biomarkers predicting survival of the first anti-TNF alpha therapy in SpA patients (P = 0.007, odds ratio (OR): 4.4, 95% confidence interval (CI) = 1.5-13.1 and P = 0.035, OR: 2.1, 95% CI = 1.1-4.4). Also, the male gender (P = 0.001, OR: 3.4, 95% CI = 1.6-7.1) associated with the NSw phenotype, whereas no association was found either with the specific diagnosis or the predominant joint involvement.
| Titolo: | The-308 TNFα and the -174 IL-6 promoter polymorphisms associate with effective anti-TNFα treatment in seronegative spondyloarthritis |
| Autori: | |
| Data di pubblicazione: | 2016 |
| Rivista: | |
| Citazione: | The-308 TNFα and the -174 IL-6 promoter polymorphisms associate with effective anti-TNFα treatment in seronegative spondyloarthritis / Fabris, M.; Quartuccio, L.; Fabro, C.; Sacco, S.; Lombardi, S.; Ramonda, R.; Biasi, D.; Punzi, D.; Adami, S.; Olivieri, I.; Curcio, F.; De Vita, S.. - In: PHARMACOGENOMICS JOURNAL. - ISSN 1470-269X. - STAMPA. - 16:3(2016), pp. 238-242. |
| Abstract: | The genetic predisposition to a long-term efficacy of anti-tumor necrosis factor (TNF)alpha treatment in seronegative spondyloarthritis (SpA) was investigated by analysing the possible correlation between several single nucleotide gene polymorphisms and the retention rate of anti-TNF alpha therapies. We compared patients needing to switch the first anti-TNF alpha (Sw, No. 64) within at least 12 months of follow-up with patients not needing to switch (NSw, No. 123), observing at least 6 months of treatment to establish anti-TNF alpha failure, leading to treatment change. Response to treatment was evaluated by standardised criteria (BASDAI for axial involvement, DAS28-EULAR for peripheral involvement). The TNF alpha -308 A allele and the interleukin (IL)-6 -174GG homozygosis resulted as independent biomarkers predicting survival of the first anti-TNF alpha therapy in SpA patients (P = 0.007, odds ratio (OR): 4.4, 95% confidence interval (CI) = 1.5-13.1 and P = 0.035, OR: 2.1, 95% CI = 1.1-4.4). Also, the male gender (P = 0.001, OR: 3.4, 95% CI = 1.6-7.1) associated with the NSw phenotype, whereas no association was found either with the specific diagnosis or the predominant joint involvement. |
| Handle: | http://hdl.handle.net/11390/1107857 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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