The present work describes the use of a magnetic porphyin (5-(4-carboxy-phenyl)-10,15,20-triphenyl-21H, 23H-porphyrin TPP) nanoconjugate (SPION-TPP) for destroying pathogenic bacteria followed by the recovery of the magnetic photosensitizer. SPION-TPP was tested for its activity against two different gram-positive bacterial strains (Staphylococcus aureus and Steptoccoccus mutans). It is observed that SPION-TPP at a very low concentration of 0.5 μM is effective in destroying gram-positive bacteria (107-108 CFU ml-1) S. aureus with several orders reduction and few orders in S. mutans. The aim of this work is to combine photoactivity against microorganisms imparted by the photosensitizer with the possibility of recovering the nanoconstruct with magnets for disposal/reuse. © 2017 World Scientific Publishing Company.
Biological evaluation of a Porphyrin-SPION nanoconjugate as an antimicrobial magnetic photosensitizer
Thandu, Merlyn M.
;Rossi, GiadaMembro del Collaboration Group
;Rizzardini, Claudia B.Membro del Collaboration Group
;Goi, DanieleMembro del Collaboration Group
;Comuzzi, ClaraSupervision
2017-01-01
Abstract
The present work describes the use of a magnetic porphyin (5-(4-carboxy-phenyl)-10,15,20-triphenyl-21H, 23H-porphyrin TPP) nanoconjugate (SPION-TPP) for destroying pathogenic bacteria followed by the recovery of the magnetic photosensitizer. SPION-TPP was tested for its activity against two different gram-positive bacterial strains (Staphylococcus aureus and Steptoccoccus mutans). It is observed that SPION-TPP at a very low concentration of 0.5 μM is effective in destroying gram-positive bacteria (107-108 CFU ml-1) S. aureus with several orders reduction and few orders in S. mutans. The aim of this work is to combine photoactivity against microorganisms imparted by the photosensitizer with the possibility of recovering the nanoconstruct with magnets for disposal/reuse. © 2017 World Scientific Publishing Company.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.