The histological grading used in the prognosis of mammary cancer in animals has usually concerned the dog, mainly following the criteria by Gilbertson and coworkers in 1983 [1] and by Lagadic and Estrada in 1990 [2]. The former method (Method 1), simplified and extended to the cat by Mandelli and co-workers in 1987 [3], is based on the evaluation of nuclear grade, duct grade and staging, each one considered separately to get prognostic information. The latter (Method 2) considers nuclear pleomorphism, tubular differentiation and number of mitosis together to obtain a single final value. In the present study, 27 canine and 16 feline mammary malignancies were diagnosed following the WHO classification (1974) and graded according to Methods 1 and 2. None of the animals had evidence of metastases at the time of surgical excision of the tumour. Chest radiographs and abdominal echographs were taken every two months for a two-year period. Two follow up parameters were evaluated: the survival time (ST) and the cancer-free interval (CFI). Method 1: staging revealed as most predictive for both species: animals bearing non-infiltrating tumours had a better prognosis than those with infiltrating neoplasms (P<0.05); no differences were instead revealed using nuclear grade as a prognostic parameter (P>0.05) in both dogs and cats. Method 2 did not produce predictive results in the dog (P<0.05 for both ST and CFI), while it probably provides prognostic information in the cat (P=0.073 for ST; P=0.027 for CFI). The histological diagnosis together with the type of growth (infiltrating or non-infiltrating) and the type of infiltration (only interstitial or with microemboli) allows each animal to be included in one of the three groups with a different risk of death and/or recurrence. These results suggest that histological diagnosis of malignancy should be completed by the application of staging to give prognostic information to single routine cases.
Observations on the correlation between histological grading and survival times of canine and feline malignant mammary tumours
Galeotti M.;
1999-01-01
Abstract
The histological grading used in the prognosis of mammary cancer in animals has usually concerned the dog, mainly following the criteria by Gilbertson and coworkers in 1983 [1] and by Lagadic and Estrada in 1990 [2]. The former method (Method 1), simplified and extended to the cat by Mandelli and co-workers in 1987 [3], is based on the evaluation of nuclear grade, duct grade and staging, each one considered separately to get prognostic information. The latter (Method 2) considers nuclear pleomorphism, tubular differentiation and number of mitosis together to obtain a single final value. In the present study, 27 canine and 16 feline mammary malignancies were diagnosed following the WHO classification (1974) and graded according to Methods 1 and 2. None of the animals had evidence of metastases at the time of surgical excision of the tumour. Chest radiographs and abdominal echographs were taken every two months for a two-year period. Two follow up parameters were evaluated: the survival time (ST) and the cancer-free interval (CFI). Method 1: staging revealed as most predictive for both species: animals bearing non-infiltrating tumours had a better prognosis than those with infiltrating neoplasms (P<0.05); no differences were instead revealed using nuclear grade as a prognostic parameter (P>0.05) in both dogs and cats. Method 2 did not produce predictive results in the dog (P<0.05 for both ST and CFI), while it probably provides prognostic information in the cat (P=0.073 for ST; P=0.027 for CFI). The histological diagnosis together with the type of growth (infiltrating or non-infiltrating) and the type of infiltration (only interstitial or with microemboli) allows each animal to be included in one of the three groups with a different risk of death and/or recurrence. These results suggest that histological diagnosis of malignancy should be completed by the application of staging to give prognostic information to single routine cases.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
