Calcium mobilization by Gi-coupled GPCRs has been perceived as a stand-alone signaling mechanism for almost 30 years. Here, Pfeil et al. report the unexpected discovery that this quintessential biological process does not occur without, and totally depends on, the heterotrimeric G protein subunit Gαq in the living cell context.
Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs
Vescovo M.;
2020-01-01
Abstract
Calcium mobilization by Gi-coupled GPCRs has been perceived as a stand-alone signaling mechanism for almost 30 years. Here, Pfeil et al. report the unexpected discovery that this quintessential biological process does not occur without, and totally depends on, the heterotrimeric G protein subunit Gαq in the living cell context.File in questo prodotto:
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