The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic

Solmi, M.; Estrade, A.; Thompson, T.; Agorastos, A.; Radua, J.; Cortese, S.; Dragioti, E.; Leisch, F.; Vancampfort, D.; Thygesen, L. C.; Aschauer, H.; Schloegelhofer, M.; Akimova, E.; Schneeberger, A.; Huber, C. G.; Hasler, G.; Conus, P.; Cuenod, K. Q. D.; von Kanel, R.; Arrondo, G.; Fusar-Poli, P.; Gorwood, P.; Llorca, P. -M.; Krebs, M. -O.; Scanferla, E.; Kishimoto, T.; Rabbani, G.; Skonieczna-Zydecka, K.; Brambilla, P.; Favaro, A.; Takamiya, A.; Zoccante, L.; Colizzi, M.; Bourgin, J.; Kaminski, K.; Moghadasin, M.; Seedat, S.; Matthews, E.; Wells, J.; Vassilopoulou, E.; Gadelha, A.; K. -P., Su; Kwon, J. S.; Kim, M.; Lee, T. Y.; Papsuev, O.; Mankova, D.; Boscutti, A.; Gerunda, C.; Saccon, D.; Righi, E.; Monaco, F.; Croatto, G.; Cereda, G.; Demurtas, J.; Brondino, N.; Veronese, N.; Enrico, P.; Politi, P.; Ciappolino, V.; Pfennig, A.; Bechdolf, A.; Meyer-Lindenberg, A.; Kahl, K. G.; Domschke, K.; Bauer, M.; Koutsouleris, N.; Winter, S.; Borgwardt, S.; Bitter, I.; Balazs, J.; Czobor, P.; Unoka, Z.; Mavridis, D.; Tsamakis, K.; Bozikas, V. P.; Tunvirachaisakul, C.; Maes, M.; Rungnirundorn, T.; Supasitthumrong, T.; Haque, A.; Brunoni, A. R.; Costardi, C. G.; Schuch, F. B.; Polanczyk, G.; Luiz, J. M.; Fonseca, L.; Aparicio, L. V.; Valvassori, S. S.; Nordentoft, M.; Vendsborg, P.; Hoffmann, S. H.; Sehli, J.; Sartorius, N.; Heuss, S.; Guinart, D.; Hamilton, J.; Kane, J.; Rubio, J.; Sand, M.; Koyanagi, A.; Solanes, A.; Andreu-Bernabeu, A.; Caceres, A. S. J.; Arango, C.; Diaz-Caneja, C. M.; Hidalgo-Mazzei, D.; Vieta, E.; Gonzalez-Penas, J.; Fortea, L.; Parellada, M.; Fullana, M. A.; Verdolini, N.; Farkova, E.; Janku, K.; Millan, M.; Honciuc, M.; Moniuszko-Malinowska, A.; Loniewski, I.; Samochowiec, J.; Kiszkiel, L.; Marlicz, M.; Sowa, P.; Marlicz, W.; Spies, G.; Stubbs, B.; Firth, J.; Sullivan, S.; Darcin, A. E.; Aksu, H.; Dilbaz, N.; Noyan, O.; Kitazawa, M.; Kurokawa, S.; Tazawa, Y.; Anselmi, A.; Cracco, C.; Machado, A. I.; Estrade, N.; De Leo, D.; Curtis, J.; Berk, M.; Ward, P.; Teasdale, S.; Rosenbaum, S.; Marx, W.; Horodnic, A. V.; Oprea, L.; Alexinschi, O.; Ifteni, P.; Turliuc, S.; Ciuhodaru, T.; Bolos, A.; Matei, V.; Nieman, D. H.; Sommer, I.; van Os, J.; van Amelsvoort, T.; Sun, C. -F.; Guu, T. -W.; Jiao, C.; Zhang, J.; Fan, J.; Zou, L.; Yu, X.; Chi, X.; de Timary, P.; van Winke, R.; Ng, B.; Pena, E.; Arellano, R.; Roman, R.; Sanchez, T.; Movina, L.; Morgado, P.; Brissos, S.; Aizberg, O.; Mosina, A.; Krinitski, D.; Mugisha, J.; Sadeghi-Bahmani, D.; Sadeghi, M.; Hadi, S.; Brand, S.; Errazuriz, A.; Crossley, N.; Ristic, D. I.; Lopez-Jaramillo, C.; Efthymiou, D.; Kuttichira, P.; Kallivayalil, R. A.; Javed, A.; Afridi, M. I.; James, B.; Seb-Akahomen, O. J.; Fiedorowicz, J.; Carvalho, A. F.; Daskalakis, J.; Yatham, L. N.; Yang, L.; Okasha, T.; Dahdouh, A.; Gerdle, B.; Tiihonen, J.; Shin, J. I.; Lee, J.; Mhalla, A.; Gaha, L.; Brahim, T.; Altynbekov, K.; Negay, N.; Nurmagambetova, S.; Jamei, Y. A.; Weiser, M.; Correll, C. U.

doi:10.1016/j.jad.2021.07.048

Background:. High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed. Methods:. The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is an international, multi-language (n=30) project involving >230 investigators from 49 countries/territories/regions, endorsed by national/international professional associations. COH-FIT is a multi-wave, on-line anonymous, cross-sectional survey [wave 1: 04/2020 until the end of the pandemic, 12 months waves 2/3 starting 6/24 months threreafter] for adults, adolescents (14-17), and children (6-13), utilizing non-probability/snowball and representative sampling. COH-FIT aims to identify non-modifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to improve social/health outcomes in the general population/vulnerable subgrous during/after COVID-19. In adults, co-primary outcomes are change from pre-COVID-19 to intra-COVID-19 in well-being (WHO-5) and a composite psychopathology P-Score. Key secondary outcomes are a P-extended score, global mental and physical health. Secondary outcomes include health-service utilization/functioning, treatment adherence, functioning, symptoms/behaviors/emotions, substance use, violence, among others. Results:. Starting 04/26/2020, up to 14/07/2021 >151,000 people from 155 countries/territories/regions and six continents have participated. Representative samples of ≥1,000 adults have been collected in 15 countries. Overall, 43.0% had prior physical disorders, 16.3% had prior mental disorders, 26.5% were health care workers, 8.2% were aged ≥65 years, 19.3% were exposed to someone infected with COVID-19, 76.1% had been in quarantine, and 2.1% had been COVID 19-positive. Limitations:. Cross-sectional survey, preponderance of non-representative participants. Conclusions:. Results from COH-FIT will comprehensively quantify the impact of COVID-19, seeking to identify high-risk groups in need for acute and long-term intervention, and inform evidence-based health policies/strategies during this/future pandemics.