Objective: To analyze the application of lung ultrasound (LUS) diagnostic approach in obstetric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and compare LUS score and symptoms of the patients. Design: A single-center observational retrospective study from October 31, 2020 to March 31, 2021. Setting: Department of Ob/Gyn at the University-Hospital of Udine, Italy. Participants: Pregnant women with SARS-CoV-2 diagnosed with reverse transcription-PCR (RT-PCR) swab test were subdivided as symptomatic and asymptomatic patients with COVID-19. Exposure: Lung ultrasound evaluation both through initial evaluation upon admission and through serial evaluations. Main Outcome: Reporting LUS findings and LUS score characteristics. Results: Symptomatic patients with COVID-19 showed a higher LUS (median 3.5 vs. 0, p < 0.001). LUS was significantly correlated with COVID-19 biomarkers as C-reactive protein (CPR; p = 0.011), interleukin-6 (p = 0.013), and pro-adrenomedullin (p = 0.02), and inversely related to arterial oxygen saturation (p = 0.004). The most frequent ultrasound findings were focal B lines (14 vs. 2) and the light beam (9 vs. 0). Conclusion: Lung ultrasound can help to manage pregnant women with SARS-CoV-2 infection during a pandemic surge. Study Registration: ClinicalTrials.gov, NCT04823234. Registered on March 29, 2021.

Lung Ultrasound Signs and Their Correlation With Clinical Symptoms in COVID-19 Pregnant Women: The “PINK-CO” Observational Study

Sala A.;Orso D.;Meroi F.;Vizzielli G.;Girometti R.;Tascini C.;Bove T.;Driul L.
2022

Abstract

Objective: To analyze the application of lung ultrasound (LUS) diagnostic approach in obstetric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and compare LUS score and symptoms of the patients. Design: A single-center observational retrospective study from October 31, 2020 to March 31, 2021. Setting: Department of Ob/Gyn at the University-Hospital of Udine, Italy. Participants: Pregnant women with SARS-CoV-2 diagnosed with reverse transcription-PCR (RT-PCR) swab test were subdivided as symptomatic and asymptomatic patients with COVID-19. Exposure: Lung ultrasound evaluation both through initial evaluation upon admission and through serial evaluations. Main Outcome: Reporting LUS findings and LUS score characteristics. Results: Symptomatic patients with COVID-19 showed a higher LUS (median 3.5 vs. 0, p < 0.001). LUS was significantly correlated with COVID-19 biomarkers as C-reactive protein (CPR; p = 0.011), interleukin-6 (p = 0.013), and pro-adrenomedullin (p = 0.02), and inversely related to arterial oxygen saturation (p = 0.004). The most frequent ultrasound findings were focal B lines (14 vs. 2) and the light beam (9 vs. 0). Conclusion: Lung ultrasound can help to manage pregnant women with SARS-CoV-2 infection during a pandemic surge. Study Registration: ClinicalTrials.gov, NCT04823234. Registered on March 29, 2021.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11390/1220673
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