The Challenge of Liver Metastases: Evolving Knowledge and Treatment

The liver is a common site of metastasis for many different tumours due to its anatomical, immunological and metabolic characteristics. For years, metastatic disease, even if oligometastatic, for many tumours was a definite limitation to the surgical option and curative intent. In recent years, the range of therapeutic options for both surgical and ablative and oncological treatment has expanded enormously. New surgical strategies to make what is initially not surgically treatable have emerged in the treatment of metastases, and new innovative medical therapies that rely not only on the local response but also on the systemic response of the patient are outlining exciting future scenarios leading to a complete evolution and revolution of the concept of metastases.