Multi-targeting approach of alphavbeta3 integrin ligands and their applications in diagnostic field and cancer therapy

Multi-target strategy is an approach where different ligands are conjugated together to give a synergic effect toward cancer cells for applications in diagnosis and cancer therapy. The target most largely in use is the integrin αvβ3 which recognizes the RGD sequence to interact with the proteins of the extracellular matrix. In the first part of this work, we analyzed the usage of RGD mimetics with radiolabeling to enhance the images of positron emission tomography, computer tomography and magnetic resonance imaging. Secondly, the interaction with drugs or with other target peptides to kill in a selective manner the cancer cells without hitting healthy cells.