CAR-T cell therapy revolutioned the therapeutic landscape of the relapsed/refractory B-cell acute lymphoblastic leukemia (ALL-R/R), improving relapse-free survival and overall survival of patients. Optimal management of late com-plications, such as hematological toxicity as well as allogeneic transplantation role in the therapeutic sequence, are specific topics currently being debated. We report a case of a young woman with ALL-B R/R extramedullary relapsed after a first allogeneic transplant and second-line immunotherapy, success-fully treated with brexucel obtaining a complete remission status confirmed after one year. We adopted a conservative strategy choosing to delay the option of a second allogeneic transplantation to manage a prologed severe hematological toxicity and to consolidate the remission obtained.
Trapianto o non trapianto dopo CAR-T: questo è il dilemma! [To transplant or not to transplant after CAR-T: that is the question!]
Patriarca F.
2026-01-01
Abstract
CAR-T cell therapy revolutioned the therapeutic landscape of the relapsed/refractory B-cell acute lymphoblastic leukemia (ALL-R/R), improving relapse-free survival and overall survival of patients. Optimal management of late com-plications, such as hematological toxicity as well as allogeneic transplantation role in the therapeutic sequence, are specific topics currently being debated. We report a case of a young woman with ALL-B R/R extramedullary relapsed after a first allogeneic transplant and second-line immunotherapy, success-fully treated with brexucel obtaining a complete remission status confirmed after one year. We adopted a conservative strategy choosing to delay the option of a second allogeneic transplantation to manage a prologed severe hematological toxicity and to consolidate the remission obtained.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
