Background Gastrointestinal tumors (GISTs) belong to a group of rare neo- plasms of the gastrointestinal tract, generally not recognized as dis- tinct pathological entities until recently. The only treatment for lo- cal disease has been radical surgical resection. No adjuvant therapy has proven effective. Purpose The purpose of the study was to establish distinct pathological entities among GISTs using new immunohistochemical markers and to determine the feasibility of other therapeutic options as an alternative to surgery. Methods In all cases in which a diagnosis of GIST was made, immuno- histochemical examination of the tumor was carried out. In patients undergoing surgery the lesion was localized. Treatment consisted of radical resection. Results There was no evidence of recurrence of disease following surgery. Consequently, no pharmacological therapy or adjuvant ra- diotherapy was deemed necessary. Conclusions GISTs comprise biologically distinct tumors. Treatment of local lesions consists of radical resection. Nevertheless, good results us- ing specific molecular therapy in advanced forms of disease have been reported in the literature.

Stromal tumor of the gastrointestinal tract: a report of 4 cases and a review of the literature

UZZAU, Alessandro
2003-01-01

Abstract

Background Gastrointestinal tumors (GISTs) belong to a group of rare neo- plasms of the gastrointestinal tract, generally not recognized as dis- tinct pathological entities until recently. The only treatment for lo- cal disease has been radical surgical resection. No adjuvant therapy has proven effective. Purpose The purpose of the study was to establish distinct pathological entities among GISTs using new immunohistochemical markers and to determine the feasibility of other therapeutic options as an alternative to surgery. Methods In all cases in which a diagnosis of GIST was made, immuno- histochemical examination of the tumor was carried out. In patients undergoing surgery the lesion was localized. Treatment consisted of radical resection. Results There was no evidence of recurrence of disease following surgery. Consequently, no pharmacological therapy or adjuvant ra- diotherapy was deemed necessary. Conclusions GISTs comprise biologically distinct tumors. Treatment of local lesions consists of radical resection. Nevertheless, good results us- ing specific molecular therapy in advanced forms of disease have been reported in the literature.
File in questo prodotto:
File Dimensione Formato  
Osp Ital Chir 2003.pdf

non disponibili

Tipologia: Altro materiale allegato
Licenza: Non pubblico
Dimensione 100.34 kB
Formato Adobe PDF
100.34 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11390/672637
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact