After informed consent was obtained and with the approval of the Local Ethical Committee, cyclosporine A (CsA) kinetics was studied in 63 psoriatic patients by giving them 2.5 mg/kg CsA orally. In order to calculate oral bioavailability, F, 22 patients were given the same dose i.v. Values of the calculated kinetic parameters were oral F = 22–63%; half-life, t 1/2β, = 11.05–13.70 h; volume of distribution, V d, = 4.00–5.02/L/kg; total body clearance, Cl, = 4.25–4.14 ml/min/kg. The area under the blood concentration time curve was more closely related to the dose (r = 0.66) than were trough levels (r = 0.52). No significant relationship was observed between the kinetic parameters studied and the age of the patient
Oral and intravenous disposition of cyclosporine in psoriatic patients.
BARALDO, Massimo;FURLANUT, Mario
1995-01-01
Abstract
After informed consent was obtained and with the approval of the Local Ethical Committee, cyclosporine A (CsA) kinetics was studied in 63 psoriatic patients by giving them 2.5 mg/kg CsA orally. In order to calculate oral bioavailability, F, 22 patients were given the same dose i.v. Values of the calculated kinetic parameters were oral F = 22–63%; half-life, t 1/2β, = 11.05–13.70 h; volume of distribution, V d, = 4.00–5.02/L/kg; total body clearance, Cl, = 4.25–4.14 ml/min/kg. The area under the blood concentration time curve was more closely related to the dose (r = 0.66) than were trough levels (r = 0.52). No significant relationship was observed between the kinetic parameters studied and the age of the patientI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
