The extension of the N-permethylation reaction of amines to aromatic amines with strong electron withdrawing substituets in o- and p-positions is reported. The reaction could be extended to the syntheses of N-permethyl-derivatives of amines of the type CH3-nDn by the use of formaldehyde, dideuteroformaldehyde, sodium borodeuteride and -hydride. Label conservation in the reaction is complete. The MS of the labelled compounds revealed extensive label exchange in the ionization chamber.

New N-Permethylations and Introduction of Deuterium Labelled Methyl Groups into Primary and Secondary Amines

VERARDO, Giancarlo;
1987

Abstract

The extension of the N-permethylation reaction of amines to aromatic amines with strong electron withdrawing substituets in o- and p-positions is reported. The reaction could be extended to the syntheses of N-permethyl-derivatives of amines of the type CH3-nDn by the use of formaldehyde, dideuteroformaldehyde, sodium borodeuteride and -hydride. Label conservation in the reaction is complete. The MS of the labelled compounds revealed extensive label exchange in the ionization chamber.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11390/680892
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