The cationic porphyrin TPrPyP4, with four propyl substituents in the pyridinium rings, is evaluated in vitro by spectroscopic and polymerase-stop assays as a G4-DNA ligand and in cultured cells as a modulator of gene transcription. A comparison with the widely used TMPyP4 is presented.
Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): a comparative study with TMPyP4
COGOI, Susanna;XODO, Luigi
2010-01-01
Abstract
The cationic porphyrin TPrPyP4, with four propyl substituents in the pyridinium rings, is evaluated in vitro by spectroscopic and polymerase-stop assays as a G4-DNA ligand and in cultured cells as a modulator of gene transcription. A comparison with the widely used TMPyP4 is presented.File in questo prodotto:
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