Objective: The aim of this study was to evaluate the effect of tamoxifen on the endometrium of post-menopausal women with breast cancer and to examine the relationship between ultrasonography, hysteroscopy and histopathologic changes. Method: Included in this longitudinal study were 303 post-menopausal women taking 20 mg daily of tamoxifen. Hysteroscopy was performed in 83 patients with an endometrial thickness of only ≥5 mm and 34 with vaginal bleeding also. Forty-five asymptomatic patients (control group) underwent hysteroscopies. Result: The most frequent outcome in patients with endometrial thickness of only ≥5 mm was an atrophic endometrium in an empty cavity (79.5%) whereas simple hyperplasia (35.3%) was found in women with vaginal bleeding. Carcinoma was diagnosed in seven cases (5.9%). In the control group, no endometrial cancer was found. Conclusion: This study suggests that patients with a thickness > 5 mm should be offered a whole hysteroscopic evaluation, whenever bleeding is reported. © 2001 International Federation of Gynecology and Obstetrics.

Endometrial histologic changes in post-menopausal breast cancer patiens using tamoxifen

MARCHESONI, Diego;DRIUL, Lorenza;FABIANI, Giuliano;DI LORETO, Carla;
2001-01-01

Abstract

Objective: The aim of this study was to evaluate the effect of tamoxifen on the endometrium of post-menopausal women with breast cancer and to examine the relationship between ultrasonography, hysteroscopy and histopathologic changes. Method: Included in this longitudinal study were 303 post-menopausal women taking 20 mg daily of tamoxifen. Hysteroscopy was performed in 83 patients with an endometrial thickness of only ≥5 mm and 34 with vaginal bleeding also. Forty-five asymptomatic patients (control group) underwent hysteroscopies. Result: The most frequent outcome in patients with endometrial thickness of only ≥5 mm was an atrophic endometrium in an empty cavity (79.5%) whereas simple hyperplasia (35.3%) was found in women with vaginal bleeding. Carcinoma was diagnosed in seven cases (5.9%). In the control group, no endometrial cancer was found. Conclusion: This study suggests that patients with a thickness > 5 mm should be offered a whole hysteroscopic evaluation, whenever bleeding is reported. © 2001 International Federation of Gynecology and Obstetrics.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11390/730238
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