The notion of the adult heart as terminally differenti- ated organ without self-renewal potential has been undermined by the existence of a subpopulation of replicating myocytes in normal and pathological states. The origin and significance of these cells has remained obscure for lack of a proper biological con- text. We report the existence of Lin c-kitPOS cells with the properties of cardiac stem cells. They are self- renewing, clonogenic, and multipotent, giving rise to myocytes, smooth muscle, and endothelial cells. When injected into an ischemic heart, these cells or their clonal progeny reconstitute well-differentiated myo- cardium, formed by blood-carrying new vessels and myocytes with the characteristics of young cells, en- compassing 70% of the ventricle. Thus, the adult heart, like the brain, is mainly composed of terminally differentiated cells, but is not a terminally differenti- ated organ because it contains stem cells supporting its regeneration. The existence of these cells opens new opportunities for myocardial repair

Adult cardiac stem cells are multipotent and support myocardial regeneration

BELTRAMI, Antonio Paolo;
2003

Abstract

The notion of the adult heart as terminally differenti- ated organ without self-renewal potential has been undermined by the existence of a subpopulation of replicating myocytes in normal and pathological states. The origin and significance of these cells has remained obscure for lack of a proper biological con- text. We report the existence of Lin c-kitPOS cells with the properties of cardiac stem cells. They are self- renewing, clonogenic, and multipotent, giving rise to myocytes, smooth muscle, and endothelial cells. When injected into an ischemic heart, these cells or their clonal progeny reconstitute well-differentiated myo- cardium, formed by blood-carrying new vessels and myocytes with the characteristics of young cells, en- compassing 70% of the ventricle. Thus, the adult heart, like the brain, is mainly composed of terminally differentiated cells, but is not a terminally differenti- ated organ because it contains stem cells supporting its regeneration. The existence of these cells opens new opportunities for myocardial repair
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11390/735454
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