The notion of the adult heart as terminally differenti- ated organ without self-renewal potential has been undermined by the existence of a subpopulation of replicating myocytes in normal and pathological states. The origin and significance of these cells has remained obscure for lack of a proper biological con- text. We report the existence of Lin c-kitPOS cells with the properties of cardiac stem cells. They are self- renewing, clonogenic, and multipotent, giving rise to myocytes, smooth muscle, and endothelial cells. When injected into an ischemic heart, these cells or their clonal progeny reconstitute well-differentiated myo- cardium, formed by blood-carrying new vessels and myocytes with the characteristics of young cells, en- compassing 70% of the ventricle. Thus, the adult heart, like the brain, is mainly composed of terminally differentiated cells, but is not a terminally differenti- ated organ because it contains stem cells supporting its regeneration. The existence of these cells opens new opportunities for myocardial repair

Adult cardiac stem cells are multipotent and support myocardial regeneration

BELTRAMI, Antonio Paolo;
2003-01-01

Abstract

The notion of the adult heart as terminally differenti- ated organ without self-renewal potential has been undermined by the existence of a subpopulation of replicating myocytes in normal and pathological states. The origin and significance of these cells has remained obscure for lack of a proper biological con- text. We report the existence of Lin c-kitPOS cells with the properties of cardiac stem cells. They are self- renewing, clonogenic, and multipotent, giving rise to myocytes, smooth muscle, and endothelial cells. When injected into an ischemic heart, these cells or their clonal progeny reconstitute well-differentiated myo- cardium, formed by blood-carrying new vessels and myocytes with the characteristics of young cells, en- compassing 70% of the ventricle. Thus, the adult heart, like the brain, is mainly composed of terminally differentiated cells, but is not a terminally differenti- ated organ because it contains stem cells supporting its regeneration. The existence of these cells opens new opportunities for myocardial repair
File in questo prodotto:
File Dimensione Formato  
CSCs Cell.pdf

non disponibili

Tipologia: Altro materiale allegato
Licenza: Non pubblico
Dimensione 1.07 MB
Formato Adobe PDF
1.07 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11390/735454
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 3062
  • ???jsp.display-item.citation.isi??? 2661
social impact