In allergic responses, B cells are driven to undergo an immunoglobulin isotype switch, shifting from immunoglobulin M to immunoglobulin E (IgE) synthesis. This process involves the rearrangement of germline DNA in the immunoglobulin heavy-chain locus and is stimulated by cytokines (IL-4 and IL-13) and CD40 activation, but the biology of the IgE-producing B cells, where they are located when the isotype switch occurs as well if the process involves an intermediate step of rearrangement to IgG1 and later to IgE, is still poorly understood.
New roots for IgE-producing B cells.
VITALE, Gaetano;PUCILLO, Carlo Ennio Michele
2012-01-01
Abstract
In allergic responses, B cells are driven to undergo an immunoglobulin isotype switch, shifting from immunoglobulin M to immunoglobulin E (IgE) synthesis. This process involves the rearrangement of germline DNA in the immunoglobulin heavy-chain locus and is stimulated by cytokines (IL-4 and IL-13) and CD40 activation, but the biology of the IgE-producing B cells, where they are located when the isotype switch occurs as well if the process involves an intermediate step of rearrangement to IgG1 and later to IgE, is still poorly understood.File in questo prodotto:
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Vitale et al New roots for IgE-producing B cells MI 2012.pdf
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