Vitamin D deficiency seems to predict the unsuccessful achievement of sustained viral response (SVR) after antiviral treatment in hepatitis C virus (HCV) difficult-to-treat geno- types. Vitamin D binding protein (GC) gene polymorphisms are known to influence vita- min D levels. This study was performed to assess whether the interaction between basal circulating vitamin D and the GC polymorphism plays a role in influencing the rate of antiviral responses in patients affected by chronic hepatitis C. In all, 206 HCV patients treated with a combination therapy of pegylated (PEG)-interferon plus ribavirin were ret- rospectively evaluated. GC rs7041 G>T, GC rs4588 C>A, and IL-28B rs12979860 C>T polymorphisms were genotyped. Frequencies of GC rs7041 G>T and rs4588 C>A poly- morphisms were: G/G 5 64 (31.1%), G/T 5 100 (48.5%), T/T 5 42 (20.4%) and C/C 5 108 (52.4%), C/A 5 84 (40.8%), A/A 5 14 (6.8%). Patients were divided into those carry- ing 3 major alleles (wildtype [WT]1: G-C/G-C, G-C/T-C, G-C/G-A, N 5 100) and the remaining (WT2: G-C/T-A, T-A/T-C, T-A/T-A, T-C/T-C, N 5 106). Four groups were identified: vitamin D 20 ng/mL and WT2, vitamin D 20 and WT1, vitamin D >20 and WT2, vitamin D >20 and WT1. In difficult-to-treat HCV genotypes the proportion of patients achieving SVR significantly increased with a linear trend from the first to the last group: 6/25 (24.0%), 9/24 (37.5%), 12/29 (41.4%), 19/29 (65.5%) (P 5 0.003). At multivariate analysis, having basal vitamin D >20 ng/mL plus the carriage of GC WT1 was found to be an independent predictor of SVR (odds ratio 4.52, P 5 0.015). Conclu- sion: In difficult-to-treat HCV genotypes, simultaneous pretreatment normal serum vita- min D levels and the carriage of GC-globulin WT isoform strongly predicts the achievement of SVR after PEG-interferon plus ribavirin antiviral therapy.

Vitamin D binding protein gene polymorphisms and baseline vitamin D levels as predictors of antiviral response in chronic hepatitis C

TONIUTTO, Pierluigi
Writing – Review & Editing
2012-01-01

Abstract

Vitamin D deficiency seems to predict the unsuccessful achievement of sustained viral response (SVR) after antiviral treatment in hepatitis C virus (HCV) difficult-to-treat geno- types. Vitamin D binding protein (GC) gene polymorphisms are known to influence vita- min D levels. This study was performed to assess whether the interaction between basal circulating vitamin D and the GC polymorphism plays a role in influencing the rate of antiviral responses in patients affected by chronic hepatitis C. In all, 206 HCV patients treated with a combination therapy of pegylated (PEG)-interferon plus ribavirin were ret- rospectively evaluated. GC rs7041 G>T, GC rs4588 C>A, and IL-28B rs12979860 C>T polymorphisms were genotyped. Frequencies of GC rs7041 G>T and rs4588 C>A poly- morphisms were: G/G 5 64 (31.1%), G/T 5 100 (48.5%), T/T 5 42 (20.4%) and C/C 5 108 (52.4%), C/A 5 84 (40.8%), A/A 5 14 (6.8%). Patients were divided into those carry- ing 3 major alleles (wildtype [WT]1: G-C/G-C, G-C/T-C, G-C/G-A, N 5 100) and the remaining (WT2: G-C/T-A, T-A/T-C, T-A/T-A, T-C/T-C, N 5 106). Four groups were identified: vitamin D 20 ng/mL and WT2, vitamin D 20 and WT1, vitamin D >20 and WT2, vitamin D >20 and WT1. In difficult-to-treat HCV genotypes the proportion of patients achieving SVR significantly increased with a linear trend from the first to the last group: 6/25 (24.0%), 9/24 (37.5%), 12/29 (41.4%), 19/29 (65.5%) (P 5 0.003). At multivariate analysis, having basal vitamin D >20 ng/mL plus the carriage of GC WT1 was found to be an independent predictor of SVR (odds ratio 4.52, P 5 0.015). Conclu- sion: In difficult-to-treat HCV genotypes, simultaneous pretreatment normal serum vita- min D levels and the carriage of GC-globulin WT isoform strongly predicts the achievement of SVR after PEG-interferon plus ribavirin antiviral therapy.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11390/872561
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