Photodynamic therapy (PDT) uses nontoxic photosensitizers and visible light to produce reactive oxygen species that kill malignant cells by apoptosis or necrosis. Silencing the antioxidant GSTA1-1 gene by siRNA sensitizes hepatic HepG2 cells to PDT with pentaphyrins. The study is a proof-of-concept for combining PDT with antigene molecules that decrease cellular response to oxidative stress.
Small Interfering RNA-Mediated Silencing of Glutathione-S-transferase A1 Sensitizes Hepatic Carcinoma Cells to Photodynamic Therapy with Pentaphyrins
Rapozzi, V.;Comuzzi, C.;Xodo, L.
2008-01-01
Abstract
Photodynamic therapy (PDT) uses nontoxic photosensitizers and visible light to produce reactive oxygen species that kill malignant cells by apoptosis or necrosis. Silencing the antioxidant GSTA1-1 gene by siRNA sensitizes hepatic HepG2 cells to PDT with pentaphyrins. The study is a proof-of-concept for combining PDT with antigene molecules that decrease cellular response to oxidative stress.File in questo prodotto:
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