Fruits and vegetables are rich in flavonoids, and ample epidemiological data show that diets rich in fruits and vegetables con-fer protection against cardiovascular, neurodegenerative and inflammatory diseases, and cancer. However, flavonoid bioavailability is re-portedly very low in mammals and the molecular mechanisms of their action are still poorly known. This review focuses on membrane transport of flavonoids, a critical determinant of their bioavailability. Cellular influx and efflux transporters are reviewed for their in-volvement in the absorption of flavonoids from the gastro-intestinal tract and their subsequent tissue distribution. A focus on the mam-malian bilirubin transporter bilitranslocase (TCDB 2.A.65.1.1) provides further insight into flavonoid bioavailability and its relationship with plasma bilirubin (an endogenous antioxidant). The general function of bilitranslocase as a flavonoid membrane transporter is further demonstrated by the occurrence of a plant homologue in organs (petals, berries) where flavonoid biosynthesis is most active. Bilitranslo-case appears associated with sub-cellular membrane compartments and operates as a flavonoid membrane transporter.

BIOAVAILABILITY OF FLAVONOIDS: A REVIEW OF THEIR MEMBRANE TRANSPORT AND THE FUNCTION OF BILITRANSLOCASE IN ANIMAL AND PLANT ORGANISMS

BRAIDOT, Enrico;PETRUSSA, Elisa;
2009-01-01

Abstract

Fruits and vegetables are rich in flavonoids, and ample epidemiological data show that diets rich in fruits and vegetables con-fer protection against cardiovascular, neurodegenerative and inflammatory diseases, and cancer. However, flavonoid bioavailability is re-portedly very low in mammals and the molecular mechanisms of their action are still poorly known. This review focuses on membrane transport of flavonoids, a critical determinant of their bioavailability. Cellular influx and efflux transporters are reviewed for their in-volvement in the absorption of flavonoids from the gastro-intestinal tract and their subsequent tissue distribution. A focus on the mam-malian bilirubin transporter bilitranslocase (TCDB 2.A.65.1.1) provides further insight into flavonoid bioavailability and its relationship with plasma bilirubin (an endogenous antioxidant). The general function of bilitranslocase as a flavonoid membrane transporter is further demonstrated by the occurrence of a plant homologue in organs (petals, berries) where flavonoid biosynthesis is most active. Bilitranslo-case appears associated with sub-cellular membrane compartments and operates as a flavonoid membrane transporter.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11390/878771
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