A 74-year-old Caucasian man with severe long-standing Palmoplantar pustular psoriasis (PPP) was treated with systemic therapy with efalizumab. Considerable improvement of PPP was observed after only 4 weeks of treatment and a complete recovery of daily activities was obtained after three months of therapy. A month later a sudden important absence of side effects; adult; aged; blood testis barrier; case report; drug withdrawal; human; lab reappearance of pustules were noted. Systemic acitretin at an initial dose of 0.5 mg/kg/d was started while continuing efalizumab. After 15 days an almost complete disappearance of pustular lesions was reobserved. The dermatosis relapsed after suspension of the retinoid, despite ongoing efalizumab.
Treatment of palmoplantar pustular psoriasis with efalizumab: a quick response with early recurrence
STINCO, Giuseppe;PATRONE, Pasquale
2008-01-01
Abstract
A 74-year-old Caucasian man with severe long-standing Palmoplantar pustular psoriasis (PPP) was treated with systemic therapy with efalizumab. Considerable improvement of PPP was observed after only 4 weeks of treatment and a complete recovery of daily activities was obtained after three months of therapy. A month later a sudden important absence of side effects; adult; aged; blood testis barrier; case report; drug withdrawal; human; lab reappearance of pustules were noted. Systemic acitretin at an initial dose of 0.5 mg/kg/d was started while continuing efalizumab. After 15 days an almost complete disappearance of pustular lesions was reobserved. The dermatosis relapsed after suspension of the retinoid, despite ongoing efalizumab.| File | Dimensione | Formato | |
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