Primary aromatic amines 1 with a variety of ring substituents are easily converted to their N-monoalkyl derivatives 3 by a simple variation of the sodium borohydride/sulfuric acid/carbonyl compound procedure previously described for their N-permethylations. The procedure is suitable for the alpha-monodeuterium labelling of the new N-substituent.
REDUCTIVE N-MONOALKYLATION OF PRIMARY AROMATIC-AMINES
VERARDO, Giancarlo;GIUMANINI, Angelo;STRAZZOLINI, Paolo;
1993-01-01
Abstract
Primary aromatic amines 1 with a variety of ring substituents are easily converted to their N-monoalkyl derivatives 3 by a simple variation of the sodium borohydride/sulfuric acid/carbonyl compound procedure previously described for their N-permethylations. The procedure is suitable for the alpha-monodeuterium labelling of the new N-substituent.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.