PTEN is a tumor suppressor gene that inhibits cell cycle progression. Recent data support that PTEN transcription is upregulated by Egr-1. The present study evaluated the immunohistochemical expression of PTEN and Egr-1 in normal thyroid and in its benign and malignant proliferative lesions. PTEN expression was cytoplasmic. The median percentage of normal cells with positive staining was 97.5%. It was similar in nodular hyperplasia, adenoma and papillary carcinoma. Follicular and undifferentiated carcinoma presented a significant decrease in the percentage of positive cells (P=0.027 and P=0.004). Egr-1 expression was nuclear. The median percentage of positivity was similar in normal tissue (29.75%), nodular hyperplasia (30.5%) and papillary carcinoma (28.25%). Adenomas, follicular carcinomas and undifferentiated carcinomas showed a significant decrease of nuclear positivity (P=0.001; P=0.001 and P=0.004, respectively).
PTEN and Egr-1 expression in thyroid proliferative lesions
DI LORETO, Carla;TELL, Gianluca;DAMANTE, Giuseppe;PUGLISI, Fabio
2005-01-01
Abstract
PTEN is a tumor suppressor gene that inhibits cell cycle progression. Recent data support that PTEN transcription is upregulated by Egr-1. The present study evaluated the immunohistochemical expression of PTEN and Egr-1 in normal thyroid and in its benign and malignant proliferative lesions. PTEN expression was cytoplasmic. The median percentage of normal cells with positive staining was 97.5%. It was similar in nodular hyperplasia, adenoma and papillary carcinoma. Follicular and undifferentiated carcinoma presented a significant decrease in the percentage of positive cells (P=0.027 and P=0.004). Egr-1 expression was nuclear. The median percentage of positivity was similar in normal tissue (29.75%), nodular hyperplasia (30.5%) and papillary carcinoma (28.25%). Adenomas, follicular carcinomas and undifferentiated carcinomas showed a significant decrease of nuclear positivity (P=0.001; P=0.001 and P=0.004, respectively).File | Dimensione | Formato | |
---|---|---|---|
Di loreto et al__Puglisi (last author) Cancer Lett 2005.pdf
non disponibili
Tipologia:
Altro materiale allegato
Licenza:
Non pubblico
Dimensione
193.02 kB
Formato
Adobe PDF
|
193.02 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.