Single diastereomeric complexes cis-RuCl2(PP)(R-Pyme) are easily obtained by a one-pot reaction of RuCl2(PPh3)3 with a Josiphos diphosphane (PP) and racemic 1-substituted-1-(pyridin-2-yl)methanamine ligands (R-Pyme; R = Me, tBu, Ph). These complexes, displaying the matched chiral PP and R-Pyme ligands, are highly active catalysts for the transfer hydrogenation of ketones affording TOF values up to 70 000 h-1 at 60 °C and ee up to 99%.
Highly Diastereoselective Formation of Ruthenium Complexes for Efficient Catalytic Asymmetric Transfer Hydrogenation
BARATTA, Walter;
2007-01-01
Abstract
Single diastereomeric complexes cis-RuCl2(PP)(R-Pyme) are easily obtained by a one-pot reaction of RuCl2(PPh3)3 with a Josiphos diphosphane (PP) and racemic 1-substituted-1-(pyridin-2-yl)methanamine ligands (R-Pyme; R = Me, tBu, Ph). These complexes, displaying the matched chiral PP and R-Pyme ligands, are highly active catalysts for the transfer hydrogenation of ketones affording TOF values up to 70 000 h-1 at 60 °C and ee up to 99%.File in questo prodotto:
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Angew. Chem. Int. Ed. 2007, 46, 7651 7654.PDF
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